Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)
1_MEQDN 6_ SPRKI 11_ QFTVP 16_ LLEPH 21_ LDPEA 26_ AEQIR 31_ RRRPT 36_ PATLV 41_ LTSDQ 46_ SSPEI 51_ DEDRI 56_ PNPHL 61_ KSTLA 66_ MSPRQ 71_ RKKMT 76_ RITPT 81_ MKELQ 86_ MMVEH 91_ HLGQQ 96_ QQGEE 101_ PEGAA 106_ ESTET 111_ QESRP 116_ PGIPD 121_ TEVES 126_ RLGTS 131_ GTAKK 136_ TAECI 141_ PKTHE 146_ RGSKE 151_ PSTKE 156_ PSTHI 161_ PPLDS 166_KGANS
1: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases