Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
1_MAAAE 6_ TQSLR 11_ EQPEM 16_ EDANS 21_ EKSIN 26_ EENGE 31_ VSEDQ 36_ SQNKH 41_ SRHKK 46_ KKHKH 51_ RSKHK 56_ KHKHS 61_ SEEDK 66_ DKKHK 71_ HKHKH 76_ KKHKR 81_ KEIID 86_ ASDKE 91_ GMSPA 96_ KRTKL 101_ DDLAL 106_ LEDLE 111_ KQRAL 116_ IKAEL 121_ DNELM 126_ EGKVQ 131_ SGMGL 136_ ILQGY 141_ ESGSE 146_ EEGEI 151_ HEKAR 156_ NGNRS 161_ STRSS 166_ STKGK 171_ LELVD 176_ NKITT 181_ KKRSK 186_ SRSKE 191_ RTRHR 196_ SDKKK 201_ SKGGI 206_ EIVKE 211_ KTTRS 216_ KSKER 221_ KKSKS 226_ PSKRS 231_ KSQDQ 236_ ARKSK 241_ SPTLR 246_ RRSQE 251_ KIGKA 256_ RSPTD 261_ DKVKI 266_ EDKSK 271_ SKDRK 276_ KSPII 281_ NESRS 286_ RDRGK 291_ KSRSP 296_ VDLRG 301_ KSKDR 306_ RSRSK 311_ ERKSK 316_ RSETD 321_ KEKKP 326_ IKSPS 331_ KDASS 336_ GKENR 341_ SPSRR 346_ PGRSP 351_ KRRSL 356_ SPKPR 361_ DKSRR 366_ SRSPL 371_ LNDRR 376_ SKQSK 381_ SPSRT 386_ LSPGR 391_ RAKSR 396_ SLERK 401_ RREPE 406_ RRRLS 411_ SPRTR 416_ PRDDI 421_ LSRRE 426_ RSKDA 431_ SPINR 436_ WSPTR 441_ RRSRS 446_ PIRRR 451_ SRSPL 456_ RRSRS 461_ PRRRS 466_ RSPRR 471_ RDRGR 476_ RSRSR 481_ LRRRS 486_ RSRGG 491_ RRRRS 496_ RSKVK 501_ EDKFK 506_ GSLSE 511_ GMKVE 516_ QESSS 521_ DDNLE 526_ DFDVE 531_ EEDEE 536_ ALIEQ 541_ RRIQR 546_ QAIVQ 551_ KYKYL 556_ AEDSN 561_ MSVPS 566_ EPSSP 571_ QSSTR 576_ TRSPS 581_ PDDIL 586_ ERVAA 591_ DVKEY 596_ ERENV 601_ DTFEA 606_ SVKAK 611_ HNLMT 616_ VEQNN 621_ GSSQK 626_ KLLAP 631_ DMFTE 636_ SDDMF 641_ AAYFD 646_ SARLR 651_ AAGIG 656_ KDFKE 661_ NPNLR 666_ DNWTD 671_ AEGYY 676_ RVNIG 681_ EVLDK 686_ RYNVY 691_ GYTGQ 696_ GVFSN 701_ VVRAR 706_ DNARA 711_ NQEVA 716_ VKIIR 721_ NNELM 726_ QKTGL 731_ KELEF 736_ LKKLN 741_ DADPD 746_ DKFHC 751_ LRLFR 756_ HFYHK 761_ QHLCL 766_ VFEPL 771_ SMNLR 776_ EVLKK 781_ YGKDV 786_ GLHIK 791_ AVRSY 796_ SQQLF 801_ LALKL 806_ LKRCN 811_ ILHAD 816_ IKPDN 821_ ILVNE 826_ SKTIL 831_ KLCDF 836_ GSASH 841_ VADND 846_ ITPYL 851_ VSRFY 856_ RAPEI 861_ IIGKS 866_ YDYGI 871_ DMWSV 876_ GCTLY 881_ ELYTG 886_ KILFP 891_ GKTNN 896_ HMLKL 901_ AMDLK 906_ GKMPN 911_ KMIRK 916_ GVFKD 921_ QHFDQ 926_ NLNFM 931_ YIEVD 936_ KVTER 941_ EKVTV 946_ MSTIN 951_ PTKDL 956_ LADLI 961_ GCQRL 966_ PEDQR 971_ KKVHQ 976_ LKDLL 981_ DQILM 986_ LDPAK 991_ RISIN 996_ QALQH 1001_AFIQE
1: Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716)