Serine incorporator 3 (Tumor differentially expressed protein 1)
1_MGAVL 6_ GVFSL 11_ ASWVP 16_ CLCSG 21_ ASCLL 26_ CSCCP 31_ NSKNS 36_ TVTRL 41_ IYAFI 46_ LLLST 51_ VVSYI 56_ MQRKE 61_ METYL 66_ KKIPG 71_ FCEGG 76_ FKIHE 81_ ADINA 86_ DKDCD 91_ VLVGY 96_ KAVYR 101_ ISFAM 106_ AIFFF 111_ VFSLL 116_ MFKVK 121_ TSKDL 126_ RAAVH 131_ NGFWF 136_ FKIAA 141_ LIGIM 146_ VGSFY 151_ IPGGY 156_ FSSVW 161_ FVVGM 166_ IGAAL 171_ FILIQ 176_ LVLLV 181_ DFAHS 186_ WNESW 191_ VNRME 196_ EGNPR 201_ LWYAA 206_ LLSFT 211_ SAFYI 216_ LSIIC 221_ VGLLY 226_ TYYTK 231_ PDGCT 236_ ENKFF 241_ ISINL 246_ ILCVV 251_ ASIIS 256_ IHPKI 261_ QEHQP 266_ RSGLL 271_ QSSLI 276_ TLYTM 281_ YLTWS 286_ AMSNE 291_ PDRSC 296_ NPNLM 301_ SFITR 306_ ITAPT 311_ LAPGN 316_ STAVV 321_ PTPTP 326_ PSKSG 331_ SLLDS 336_ DNFIG 341_ LFVFV 346_ LCLLY 351_ SSIRT 356_ STNSQ 361_ VDKLT 366_ LSGSD 371_ SVILG 376_ DTTTS 381_ GASDE 386_ EDGQP 391_ RRAVD 396_ NEKEG 401_ VQYSY 406_ SLFHL 411_ MLCLA 416_ SLYIM 421_ MTLTS 426_ WYSPD 431_ AKFQS 436_ MTSKW 441_ PAVWV 446_ KISSS 451_ WVCLL 456_ LYVWT 461_ LVAPL 466_VLTSR
1: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505)