Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
1_MGEHG 6_ LELAS 11_ MIPAL 16_ RELGS 21_ ATPEE 26_ YNTVV 31_ QKPRQ 36_ ILCQF 41_ IDRIL 46_ TDVNV 51_ VAVEL 56_ VKKTD 61_ SQPTS 66_ VMLLD 71_ FIQHI 76_ MKSSP 81_ LMFVN 86_ VSGSH 91_ EAKGS 96_ CIEFS 101_ NWIIT 106_ RLLRI 111_ AATPS 116_ CHLLH 121_ KKICE 126_ VICSL 131_ LFLFK 136_ SKSPA 141_ IFGVL 146_ TKELL 151_ QLFED 156_ LVYLH 161_ RRNVM 166_ GHAVE 171_ WPVVM 176_ SRFLS 181_ QLDEH 186_ MGYLQ 191_ SAPLQ 196_ LMSMQ 201_ NLEFI 206_ EVTLL 211_ MVLTR 216_ IIAIV 221_ FFRRQ 226_ ELLLW 231_ QIGCV 236_ LLEYG 241_ SPKIK 246_ SLAIS 251_ FLTEL 256_ FQLGG 261_ LPAQP 266_ ASTFF 271_ SSFLE 276_ LLKHL 281_ VEMDT 286_ DQLKL 291_ YEEPL 296_ SKLIK 301_ TLFPF 306_ EAEAY 311_ RNIEP 316_ VYLNM 321_ LLEKL 326_ CVMFE 331_ DGVLM 336_ RLKSD 341_ LLKAA 346_ LCHLL 351_ QYFLK 356_ FVPAG 361_ YESAL 366_ QVRKV 371_ YVRNI 376_ CKALL 381_ DVLGI 386_ EVDAE 391_ YLLGP 396_ LYAAL 401_ KMESM 406_ EIIEE 411_ IQCQT 416_ QQENL 421_ SSNSD 426_ GISPK 431_ RRRLS 436_ SSLNP 441_ SKRAP 446_ KQTEE 451_ IKHVD 456_ MNQKS 461_ ILWSA 466_ LKQKA 471_ ESLQI 476_ SLEYS 481_ GLKNP 486_ VIEML 491_ EGIAV 496_ VLQLT 501_ ALCTV 506_ HCSHQ 511_ NMNCR 516_ TFKDC 521_ QHKSK 526_ KKPSV 531_ VITWM 536_ SLDFY 541_ TKVLK 546_ SCRSL 551_ LESVQ 556_ KLDLE 561_ ATIDK 566_ VVKIY 571_ DALIY 576_ MQVNS 581_ SFEDH 586_ ILEDL 591_ CGMLS 596_ LPWIY 601_ SHSDD 606_ GCLKL 611_ TTFAA 616_ NLLTL 621_ SCRIS 626_ DSYSP 631_ QAQSR 636_ CVFLL 641_ TLFPR 646_ RIFLE 651_ WRTAV 656_ YNWAL 661_ QSSHE 666_ VIRAS 671_ CVSGF 676_ FILLQ 681_ QQNSC 686_ NRVPK 691_ ILIDK 696_ VKDDS 701_ DIVKK 706_ EFASI 711_ LGQLV 716_ CTLHG 721_ MFYLT 726_ SSLTE 731_ PFSEH 736_ GHVDL 741_ FCRNL 746_ KATSQ 751_ HECSS 756_ SQLKA 761_ SVCKP 766_ FLFLL 771_ KKKIP 776_ SPVKL 781_ AFIDN 786_ LHHLC 791_ KHLDF 796_ REDET 801_ DVKAV 806_ LGTLL 811_ NLMED 816_ PDKDV 821_ RVAFS 826_ GNIKH 831_ ILESL 836_ DSEDG 841_ FIKEL 846_ FVLRM 851_ KEAYT 856_ HAQIS 861_ RNNEL 866_ KDTLI 871_ LTTGD 876_ IGRAA 881_ KGDLV 886_ PFALL 891_ HLLHC 896_ LLSKS 901_ ASVSG 906_ AAYTE 911_ IRALV 916_ AAKSV 921_ KLQSF 926_ FSQYK 931_ KPICQ 936_ FLVES 941_ LHSSQ 946_ MTALP 951_ NTPCQ 956_ NADVR 961_ KQDVA 966_ HQREM 971_ ALNTL 976_ SEIAN 981_ VFDFP 986_ DLNRF 991_ LTRTL 996_ QVLLP 1001_ DLAAK 1006_ ASPAA 1011_ SALIR 1016_ TLGKQ 1021_ LNVNR 1026_ REILI 1031_ NNFKY 1036_ IFSHL 1041_ VCSCS 1046_ KDELE 1051_ RALHY 1056_ LKNET 1061_ EIELG 1066_ SLLRQ 1071_ DFQGL 1076_ HNELL 1081_ LRIGE 1086_ HYQQV 1091_ FNGLS 1096_ ILASF 1101_ ASSDD 1106_ PYQGP 1111_ RDIIS 1116_ PELMA 1121_ DYLQP 1126_ KLLGI 1131_ LAFFN 1136_ MQLLS 1141_ SSVGI 1146_ EDKKM 1151_ ALNSL 1156_ MSLMK 1161_ LMGPK 1166_ HVSSV 1171_ RVKMM 1176_ TTLRT 1181_ GLRFK 1186_ DDFPE 1191_ LCCRA 1196_ WDCFV 1201_ RCLDH 1206_ ACLGS 1211_ LLSHV 1216_ IVALL 1221_ PLIHI 1226_ QPKET 1231_ AAIFH 1236_ YLIIE 1241_ NRDAV 1246_ QDFLH 1251_ EIYFL 1256_ PDHPE 1261_ LKKIK 1266_ AVLQE 1271_ YRKET 1276_ SESTD 1281_ LQTTL 1286_ QLSMK 1291_ AIQHE 1296_ NVDVR 1301_ IHALT 1306_ SLKET 1311_ LYKNQ 1316_ EKLIK 1321_ YATDS 1326_ ETVEP 1331_ IISQL 1336_ VTVLL 1341_ KGCQD 1346_ ANSQA 1351_ RLLCG 1356_ ECLGE 1361_ LGAID 1366_ PGRLD 1371_ FSTTE 1376_ TQGKD 1381_ FTFVT 1386_ GVEDS 1391_ SFAYG 1396_ LLMEL 1401_ TRAYL 1406_ AYADN 1411_ SRAQD 1416_ SAAYA 1421_ IQELL 1426_ SIYDC 1431_ REMET 1436_ NGPGH 1441_ QLWRR 1446_ FPEHV 1451_ REILE 1456_ PHLNT 1461_ RYKSS 1466_ QKSTD 1471_ WSGVK 1476_ KPIYL 1481_ SKLGS 1486_ NFAEW 1491_ SASWA 1496_ GYLIT 1501_ KVRHD 1506_ LASKI 1511_ FTCCS 1516_ IMMKH 1521_ DFKVT 1526_ IYLLP 1531_ HILVY 1536_ VLLGC 1541_ NQEDQ 1546_ QEVYA 1551_ EIMAV 1556_ LKHDD 1561_ QHTIN 1566_ TQDIA 1571_ SDLCQ 1576_ LSTQT 1581_ VFSML 1586_ DHLTQ 1591_ WARHK 1596_ FQALK 1601_ AEKCP 1606_ HSKSN 1611_ RNKVD 1616_ SMVST 1621_ VDYED 1626_ YQSVT 1631_ RFLDL 1636_ IPQDT 1641_ LAVAS 1646_ FRSKA 1651_ YTRAV 1656_ MHFES 1661_ FITEK 1666_ KQNIQ 1671_ EHLGF 1676_ LQKLY 1681_ AAMHE 1686_ PDGVA 1691_ GVSAI 1696_ RKAEP 1701_ SLKEQ 1706_ ILEHE 1711_ SLGLL 1716_ RDATA 1721_ CYDRA 1726_ IQLEP 1731_ DQIIH 1736_ YHGVV 1741_ KSMLG 1746_ LGQLS 1751_ TVITQ 1756_ VNGVH 1761_ ANRSE 1766_ WTDEL 1771_ NTYRV 1776_ EAAWK 1781_ LSQWD 1786_ LVENY 1791_ LAADG 1796_ KSTTW 1801_ SVRLG 1806_ QLLLS 1811_ AKKRD 1816_ ITAFY 1821_ DSLKL 1826_ VRAEQ 1831_ IVPLS 1836_ AASFE 1841_ RGSYQ 1846_ RGYEY 1851_ IVRLH 1856_ MLCEL 1861_ EHSIK 1866_ PLFQH 1871_ SPGDS 1876_ SQEDS 1881_ LNWVA 1886_ RLEMT 1891_ QNSYR 1896_ AKEPI 1901_ LALRR 1906_ ALLSL 1911_ NKRPD 1916_ YNEMV 1921_ GECWL 1926_ QSARV 1931_ ARKAG 1936_ HHQTA 1941_ YNALL 1946_ NAGES 1951_ RLAEL 1956_ YVERA 1961_ KWLWS 1966_ KGDVH 1971_ QALIV 1976_ LQKGV 1981_ ELCFP 1986_ ENETP 1991_ PEGKN 1996_ MLIHG 2001_ RAMLL 2006_ VGRFM 2011_ EETAN 2016_ FESNA 2021_ IMKKY 2026_ KDVTA 2031_ CLPEW 2036_ EDGHF 2041_ YLAKY 2046_ YDKLM 2051_ PMVTD 2056_ NKMEK 2061_ QGDLI 2066_ RYIVL 2071_ HFGRS 2076_ LQYGN 2081_ QFIYQ 2086_ SMPRM 2091_ LTLWL 2096_ DYGTK 2101_ AYEWE 2106_ KAGRS 2111_ DRVQM 2116_ RNDLG 2121_ KINKV 2126_ ITEHT 2131_ NYLAP 2136_ YQFLT 2141_ AFSQL 2146_ ISRIC 2151_ HSHDE 2156_ VFVVL 2161_ MEIIA 2166_ KVFLA 2171_ YPQQA 2176_ MWMMT 2181_ AVSKS 2186_ SYPMR 2191_ VNRCK 2196_ EILNK 2201_ AIHMK 2206_ KSLEK 2211_ FVGDA 2216_ TRLTD 2221_ KLLEL 2226_ CNKPV 2231_ DGSSS 2236_ TLSMS 2241_ THFKM 2246_ LKKLV 2251_ EEATF 2256_ SEILI 2261_ PLQSV 2266_ MIPTL 2271_ PSILG 2276_ THANH 2281_ ASHEP 2286_ FPGHW 2291_ AYIAG 2296_ FDDMV 2301_ EILAS 2306_ LQKPK 2311_ KISLK 2316_ GSDGK 2321_ FYIMM 2326_ CKPKD 2331_ DLRKD 2336_ CRLME 2341_ FNSLI 2346_ NKCLR 2351_ KDAES 2356_ RRREL 2361_ HIRTY 2366_ AVIPL 2371_ NDECG 2376_ IIEWV 2381_ NNTAG 2386_ LRPIL 2391_ TKLYK 2396_ EKGVY 2401_ MTGKE 2406_ LRQCM 2411_ LPKSA 2416_ ALSEK 2421_ LKVFR 2426_ EFLLP 2431_ RHPPI 2436_ FHEWF 2441_ LRTFP 2446_ DPTSW 2451_ YSSRS 2456_ AYCRS 2461_ TAVMS 2466_ MVGYI 2471_ LGLGD 2476_ RHGEN 2481_ ILFDS 2486_ LTGEC 2491_ VHVDF 2496_ NCLFN 2501_ KGETF 2506_ EVPEI 2511_ VPFRL 2516_ THNMV 2521_ NGMGP 2526_ MGTEG 2531_ LFRRA 2536_ CEVTM 2541_ RLMRD 2546_ QREPL 2551_ MSVLK 2556_ TFLHD 2561_ PLVEW 2566_ SKPVK 2571_ GHSKA 2576_ PLNET 2581_ GEVVN 2586_ EKAKT 2591_ HVLDI 2596_ EQRLQ 2601_ GVIKT 2606_ RNRVT 2611_ GLPLS 2616_ IEGHV 2621_ HYLIQ 2626_ EATDE 2631_ NLLCQ 2636_MYLGW
1: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity)