Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
1_MSGGS 6_ SCSQT 11_ PSRAI 16_ PATRR 21_ VVLGD 26_ GVQLP 31_ PGDYS 36_ TTPGG 41_ TLFST 46_ TPGGT 51_ RIIYD 56_ RKFLM 61_ ECRNS 66_ PVTKT 71_ PPRDL 76_ PTIPG 81_ VTSPS 86_ SDEPP 91_ MEASQ 96_ SHLRN 101_ SPEDK 106_ RAGGE 111_ESQFE
1: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways