Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)
1_MSSSA 6_ GSGHQ 11_ PSQSR 16_ AIPTR 21_ TVAIS 26_ DAAQL 31_ PHDYC 36_ TTPGG 41_ TLFST 46_ TPGGT 51_ RIIYD 56_ RKFLL 61_ DRRNS 66_ PMAQT 71_ PPCHL 76_ PNIPG 81_ VTSPG 86_ TLIED 91_ SKVEV 96_ NNLNN 101_ LNNHD 106_ RKHAV 111_GDDAQ
1: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity)