Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
1_MAQTQ 6_ GTRRK 11_ VCYYY 16_ DGDVG 21_ NYYYG 26_ QGHPM 31_ KPHRI 36_ RMTHN 41_ LLLNY 46_ GLYRK 51_ MEIYR 56_ PHKAN 61_ AEEMT 66_ KYHSD 71_ DYIKF 76_ LRSIR 81_ PDNMS 86_ EYSKQ 91_ MQRFN 96_ VGEDC 101_ PVFDG 106_ LFEFC 111_ QLSTG 116_ GSVAS 121_ AVKLN 126_ KQQTD 131_ IAVNW 136_ AGGLH 141_ HAKKS 146_ EASGF 151_ CYVND 156_ IVLAI 161_ LELLK 166_ YHQRV 171_ LYIDI 176_ DIHHG 181_ DGVEE 186_ AFYTT 191_ DRVMT 196_ VSFHK 201_ YGEYF 206_ PGTGD 211_ LRDIG 216_ AGKGK 221_ YYAVN 226_ YPLRD 231_ GIDDE 236_ SYEAI 241_ FKPVM 246_ SKVME 251_ MFQPS 256_ AVVLQ 261_ CGSDS 266_ LSGDR 271_ LGCFN 276_ LTIKG 281_ HAKCV 286_ EFVKS 291_ FNLPM 296_ LMLGG 301_ GGYTI 306_ RNVAR 311_ CWTYE 316_ TAVAL 321_ DTEIP 326_ NELPY 331_ NDYFE 336_ YFGPD 341_ FKLHI 346_ SPSNM 351_ TNQNT 356_ NEYLE 361_ KIKQR 366_ LFENL 371_ RMLPH 376_ APGVQ 381_ MQAIP 386_ EDAIP 391_ EESGD 396_ EDEDD 401_ PDKRI 406_ SICSS 411_ DKRIA 416_ CEEEF 421_ SDSEE 426_ EGEGG 431_ RKNSS 436_ NFKKA 441_ KRVKT 446_ EDEKE 451_ KDPEE 456_ KKEVT 461_ EEEKT 466_ KEEKP 471_ EAKGV 476_KEEVK
1: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827)