Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
1_MATTV 6_ TCTRF 11_ TDEYQ 16_ LYEDI 21_ GKGAF 26_ SVVRR 31_ CVKLC 36_ TGHEY 41_ AAKII 46_ NTKKL 51_ SARDH 56_ QKLER 61_ EARIC 66_ RLLKH 71_ SNIVR 76_ LHDSI 81_ SEEGF 86_ HYLVF 91_ DLVTG 96_ GELFE 101_ DIVAR 106_ EYYSE 111_ ADASH 116_ CIQQI 121_ LEAVL 126_ HCHQM 131_ GVVHR 136_ DLKPE 141_ NLLLA 146_ SKCKG 151_ AAVKL 156_ ADFGL 161_ AIEVQ 166_ GDQQA 171_ WFGFA 176_ GTPGY 181_ LSPEV 186_ LRKEA 191_ YGKPV 196_ DIWAC 201_ GVILY 206_ ILLVG 211_ YPPFW 216_ DEDQH 221_ KLYQQ 226_ IKAGA 231_ YDFPS 236_ PEWDT 241_ VTPEA 246_ KNLIN 251_ QMLTI 256_ NPAKR 261_ ITAHE 266_ ALKHP 271_ WVCQR 276_ STVAS 281_ MMHRQ 286_ ETVEC 291_ LKKFN 296_ ARRKL 301_ KGAIL 306_ TTMLA 311_ TRNFS 316_ VGRQT 321_ TAPAT 326_ MSTAA 331_ SGTTM 336_ GLVEQ 341_ AKSLL 346_ NKKAD 351_ GVKPQ 356_ TNSTK 361_ NSAAA 366_ TSPKG 371_ TLPPA 376_ ALEPQ 381_ TTVIH 386_ NPVDG 391_ IKESS 396_ DSANT 401_ TIEDE 406_ DAKAP 411_ RVPDI 416_ LSSVR 421_ RGSGA 426_ PEAEG 431_ PLPCP 436_ SPAPF 441_ SPLPA 446_ PSPRI 451_ SDILN 456_ SVRRG 461_ SGTPE 466_ AEGPL 471_ SAGPP 476_ PCLSP 481_ ALLGP 486_ LSSPS 491_ PRISD 496_ ILNSV 501_ RRGSG 506_ TPEAE 511_ GPSPV 516_ GPPPC 521_ PSPTI 526_ PGPLP 531_ TPSRK 536_ QEIIK 541_ TTEQL 546_ IEAVN 551_ NGDFE 556_ AYAKI 561_ CDPGL 566_ TSFEP 571_ EALGN 576_ LVEGM 581_ DFHRF 586_ YFENL 591_ LAKNS 596_ KPIHT 601_ TILNP 606_ HVHVI 611_ GEDAA 616_ CIAYI 621_ RLTQY 626_ IDGQG 631_ RPRTS 636_ QSEET 641_ RVWHR 646_ RDGKW 651_ QNVHF 656_ HCSGA 661_PVAPL
1: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741)