Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
1_MASTT 6_ TCTRF 11_ TDEYQ 16_ LFEEL 21_ GKGAF 26_ SVVRR 31_ CMKIP 36_ TGQEY 41_ AAKII 46_ NTKKL 51_ SARDH 56_ QKLER 61_ EARIC 66_ RLLKH 71_ PNIVR 76_ LHDSI 81_ SEEGF 86_ HYLVF 91_ DLVTG 96_ GELFE 101_ DIVAR 106_ EYYSE 111_ ADASH 116_ CIQQI 121_ LESVN 126_ HCHLN 131_ GIVHR 136_ DLKPE 141_ NLLLA 146_ SKSKG 151_ AAVKL 156_ ADFGL 161_ AIEVQ 166_ GDQQA 171_ WFGFA 176_ GTPGY 181_ LSPEV 186_ LRKDP 191_ YGKPV 196_ DMWAC 201_ GVILY 206_ ILLVG 211_ YPPFW 216_ DEDQH 221_ RLYQQ 226_ IKAGA 231_ YDFPS 236_ PEWDT 241_ VTPEA 246_ KDLIN 251_ KMLTI 256_ NPAKR 261_ ITASE 266_ ALKHP 271_ WICQR 276_ STVAS 281_ MMHRQ 286_ ETVDC 291_ LKKFN 296_ ARRKL 301_ KGAIL 306_ TTMLA 311_ TRNFS 316_ AAKSL 321_ LKKPD 326_ GVKES 331_ TESSN 336_ TTIED 341_ EDVKA 346_ RKQEI 351_ IKVTE 356_ QLIEA 361_ INNGD 366_ FEAYT 371_ KICDP 376_ GLTAF 381_ EPEAL 386_ GNLVE 391_ GMDFH 396_ RFYFE 401_ NALSK 406_ SNKPI 411_ HTIIL 416_ NPHVH 421_ LVGDD 426_ AACIA 431_ YIRLT 436_ QYMDG 441_ SGMPK 446_ TMQSE 451_ ETRVW 456_ HRRDG 461_ KWQNV 466_ HFHRS 471_ GSPTV 476_ PIKPP 481_ CIPNG 486_ KENFS 491_GGTSL
1: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)