Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin)
1_MADPK 6_ YADLP 11_ GIARN 16_ EPDVY 21_ ETSDL 26_ PEDDQ 31_ AEFDA 36_ EELTS 41_ TSVEH 46_ IIVNP 51_ NAAYD 56_ KFKDK 61_ RVGTK 66_ GLDFS 71_ DRIGK 76_ TKRTG 81_ YESGE 86_ YEMLG 91_ EGLGV 96_ KETPQ 101_ QKYQR 106_ LLHEV 111_ QELTT 116_ EVEKI 121_ KTTVK 126_ ESATE 131_ EKLTP 136_ VLLAK 141_ QLAAL 146_ KQQLV 151_ ASHLE 156_ KLLGP 161_ DAAIN 166_ LTDPD 171_ GALAK 176_ RLLLQ 181_ LEATK 186_ NSKGG 191_ SGGKT 196_ TGTPP 201_ DSSLV 206_ TYELH 211_ SRPEQ 216_ DKFSQ 221_ AAKVA 226_ ELEKR 231_ LTELE 236_ TAVRC 241_ DQDAQ 246_ NPLSA 251_ GLQGA 256_ CLMET 261_ VELLQ 266_ AKVSA 271_ LDLAV 276_ LDQVE 281_ ARLQS 286_ VLGKV 291_ NEIAK 296_ HKASV 301_ EDADT 306_ QSKVH 311_ QLYET 316_ IQRWS 321_ PIAST 326_ LPELV 331_ QRLVT 336_ IKQLH 341_ EQAMQ 346_ FGQLL 351_ THLDT 356_ TQQMI 361_ ANSLK 366_ DNTTL 371_ LTQVQ 376_ TTMRE 381_ NLATV 386_ EGNFA 391_ SIDER 396_MKKLG
1: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)