Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3)
1_MTKSY 6_ SESGL 11_ MGEPQ 16_ PQGPP 21_ SWTDE 26_ CLSSQ 31_ DEEHE 36_ ADKKE 41_ DDLET 46_ MNAEE 51_ DSLRN 56_ GGEEE 61_ DEDED 66_ LEEEE 71_ EEEEE 76_ DDDQK 81_ PKRRG 86_ PKKKK 91_ MTKAR 96_ LERFK 101_ LRRMK 106_ ANARE 111_ RNRMH 116_ GLNAA 121_ LDNLR 126_ KVVPC 131_ YSKTQ 136_ KLSKI 141_ ETLRL 146_ AKNYI 151_ WALSE 156_ ILRSG 161_ KSPDL 166_ VSFVQ 171_ TLCKG 176_ LSQPT 181_ TNLVA 186_ GCLQL 191_ NPRTF 196_ LPEQN 201_ QDMPP 206_ HLPTA 211_ SASFP 216_ VHPYS 221_ YQSPG 226_ LPSPP 231_ YGTMD 236_ SSHVF 241_ HVKPP 246_ PHAYS 251_ AALEP 256_ FFESP 261_ LTDCT 266_ SPSFD 271_ GPLSP 276_ PLSIN 281_ GNFSF 286_ KHEPS 291_ AEFEK 296_ NYAFT 301_ MHYPA 306_ ATLAG 311_ AQSHG 316_ SIFSG 321_ TAAPR 326_ CEIPI 331_ DNIMS 336_ FDSHS 341_ HHERV 346_ MSAQL 351_NAIFH
1: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)