Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)
1_MVNSS 6_ RVQPQ 11_ QPGDA 16_ KRPPA 21_ PRAPD 26_ PGRLM 31_ AGCAA 36_ VGASL 41_ AAPGG 46_ LCEQR 51_ GLEIE 56_ MQRIR 61_ QAAAR 66_ DPPAG 71_ AAASP 76_ SPPLS 81_ SCSRQ 86_ AWSRD 91_ NPGFE 96_ AEEEE 101_ EEVEG 106_ EEGGM 111_ VVEMD 116_ VEWRP 121_ GSRRS 126_ AASSA 131_ VSSVG 136_ ARSRG 141_ LGGYH 146_ GAGHP 151_ SGRRR 156_ RREDQ 161_ GPPCP 166_ SPVGG 171_ GDPLH 176_ RHLPL 181_ EGQPP 186_ RVAWA 191_ ERLVR 196_ GLRGL 201_ WGTRL 206_ MEESS 211_ TNREK 216_ YLKSV 221_ LRELV 226_ TYLLF 231_ LIVLC 236_ ILTYG 241_ MMSSN 246_ VYYYT 251_ RMMSQ 256_ LFLDT 261_ PVSKT 266_ EKTNF 271_ KTLSS 276_ MEDFW 281_ KFTEG 286_ SLLDG 291_ LYWKM 296_ QPSNQ 301_ TEADN 306_ RSFIF 311_ YENLL 316_ LGVPR 321_ IRQLR 326_ VRNGS 331_ CSIPQ 336_ DLRDE 341_ IKECY 346_ DVYSV 351_ SSEDR 356_ APFGP 361_ RNGTA 366_ WIYTS 371_ EKDLN 376_ GSSHW 381_ GIIAT 386_ YSGAG 391_ YYLDL 396_ SRTRE 401_ ETAAQ 406_ VASLK 411_ KNVWL 416_ DRGTR 421_ ATFID 426_ FSVYN 431_ ANINL 436_ FCVVR 441_ LLVEF 446_ PATGG 451_ VIPSW 456_ QFQPL 461_ KLIRY 466_ VTTFD 471_ FFLAA 476_ CEIIF 481_ CFFIF 486_ YYVVE 491_ EILEI 496_ RIHKL 501_ HYFRS 506_ FWNCL 511_ DVVIV 516_ VLSVV 521_ AIGIN 526_ IYRTS 531_ NVEVL 536_ LQFLE 541_ DQNTF 546_ PNFEH 551_ LAYWQ 556_ IQFNN 561_ IAAVT 566_ VFFVW 571_ IKLFK 576_ FINFN 581_ RTMSQ 586_ LSTTM 591_ SRCAK 596_ DLFGF 601_ AIMFF 606_ IIFLA 611_ YAQLA 616_ YLVFG 621_ TQVDD 626_ FSTFQ 631_ ECIFT 636_ QFRII 641_ LGDIN 646_ FAEIE 651_ EANRV 656_ LGPIY 661_ FTTFV 666_ FFMFF 671_ ILLNM 676_ FLAII 681_ NDTYS 686_ EVKSD 691_ LAQQK 696_ AEMEL 701_ SDLIR 706_ KGYHK 711_ ALVKL 716_ KLKKN 721_ TVDDI 726_ SESLR 731_ QGGGK 736_ LNFDE 741_ LRQDL 746_ KGKGH 751_ TDAEI 756_ EAIFT 761_ KYDQD 766_ GDQEL 771_ TEHEH 776_ QQMRD 781_ DLEKE 786_ REDLD 791_ LDHSS 796_ LPRPM 801_ SSRSF 806_ PRSLD 811_ DSEED 816_ DDEDS 821_ GHSSR 826_ RRGSI 831_ SSGVS 836_ YEEFQ 841_ VLVRR 846_ VDRME 851_ HSIGS 856_ IVSKI 861_ DAVIV 866_ KLEIM 871_ ERAKL 876_ KRREV 881_ LGRLL 886_ DGVAE 891_ DERLG 896_ RDSEI 901_ HREQM 906_ ERLVR 911_ EELER 916_ WESDD 921_ AASQI 926_ SHGLG 931_ TPVGL 936_ NGQPR 941_ PRSSR 946_ PSSSQ 951_ STEGM 956_ EGAGG 961_NGSSN
1: Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity)