Interferon regulatory factor 5 (IRF-5)
1_MNQSI 6_ PVAPT 11_ PPRRV 16_ RLKPW 21_ LVAQV 26_ NSCQY 31_ PGLQW 36_ VNGEK 41_ KLFCI 46_ PWRHA 51_ TRHGP 56_ SQDGD 61_ NTIFK 66_ AWAKE 71_ TGKYT 76_ EGVDE 81_ ADPAK 86_ WKANL 91_ RCALN 96_ KSRDF 101_ RLIYD 106_ GPRDM 111_ PPQPY 116_ KIYEV 121_ CSNGP 126_ APTDS 131_ QPPED 136_ YSFGA 141_ GEEEE 146_ EEEEL 151_ QRMLP 156_ SLSLT 161_ EDVKW 166_ PPTLQ 171_ PPTLR 176_ PPTLQ 181_ PPTLQ 186_ PPVVL 191_ GPPAP 196_ DPSPL 201_ APPPG 206_ NPAGF 211_ RELLS 216_ EVLEP 221_ GPLPA 226_ SLPPA 231_ GEQLL 236_ PDLLI 241_ SPHML 246_ PLTDL 251_ EIKFQ 256_ YRGRP 261_ PRALT 266_ ISNPH 271_ GCRLF 276_ YSQLE 281_ ATQEQ 286_ VELFG 291_ PISLE 296_ QVRFP 301_ SPEDI 306_ PSDKQ 311_ RFYTN 316_ QLLDV 321_ LDRGL 326_ ILQLQ 331_ GQDLY 336_ AIRLC 341_ QCKVF 346_ WSGPC 351_ ASAHD 356_ SCPNP 361_ IQREV 366_ KTKLF 371_ SLEHF 376_ LNELI 381_ LFQKG 386_ QTNTP 391_ PPFEI 396_ FFCFG 401_ EEWPD 406_ RKPRE 411_ KKLIT 416_ VQVVP 421_ VAARL 426_ LLEMF 431_ SGELS 436_ WSADS 441_ IRLQI 446_ SNPDL 451_ KDRMV 456_ EQFKE 461_ LHHIW 466_ QSQQR 471_ LQPVA 476_ QAPPG 481_ AGLGV 486_ GQGPW 491_PMHPA
1: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148)