SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)
1_MALTS 6_ FLPAP 11_ TQLSQ 16_ DQLEA 21_ EEKAR 26_ SQRSR 31_ QTSLV 36_ SSRRE 41_ PPPYG 46_ YRKGW 51_ IPRLL 56_ EDFGD 61_ GGAFP 66_ EIHVA 71_ QYPLD 76_ MGRKK 81_ KMSNA 86_ LAIQV 91_ DSEGK 96_ IKYDA 101_ IARQG 106_ QSKDK 111_ VIYSK 116_ YTDLV 121_ PKEVM 126_ NADDP 131_ DLQRP 136_ DEEAI 141_ KEITE 146_ KTRVA 151_ LEKSV 156_ SQKVA 161_ AAMPV 166_ RAADK 171_ LAPAQ 176_ YIRYT 181_ PSQQG 186_ VAFNS 191_ GAKQR 196_ VIRMV 201_ EMQKD 206_ PMEPP 211_ RFKIN 216_ KKIPR 221_ GPPSP 226_ PAPVM 231_ HSPSR 236_ KMTVK 241_ EQQEW 246_ KIPPC 251_ ISNWK 256_ NAKGY 261_ TIPLD 266_ KRLAA 271_ DGRGL 276_ QTVHI 281_ NENFA 286_ KLAEA 291_ LYIAD 296_ RKARE 301_ AVEMR 306_ AQVER 311_ KMAQK 316_ EKEKH 321_ EEKLR 326_ EMAQK 331_ ARERR 336_ AGIKT 341_ HVEKE 346_ DGEAR 351_ ERDEI 356_ RHDRR 361_ KERQH 366_ DRNLS 371_ RAAPD 376_ KRSKL 381_ QRNEN 386_ RDISE 391_ VIALG 396_ VPNPR 401_ TSNEV 406_ QYDQR 411_ LFNQS 416_ KGMDS 421_ GFAGG 426_ EDEIY 431_ NVYDQ 436_ AWRGG 441_ KDMAQ 446_ SIYRP 451_ SKNLD 456_ KDMYG 461_ DDLEA 466_ RIKTN 471_ RFVPD 476_ KEFSG 481_ SDRRQ 486_ RGREG 491_ PVQFE 496_ EDPFG 501_ LDKFL 506_ EEAKQ 511_ HGGSK 516_ RPSDS 521_ SRPKE 526_ HEHEG 531_KKRRK
1: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD
2: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter
3: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters