Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta)
1_MEPRD 6_ GSPEA 11_ RSSDS 16_ ESASA 21_ SSSGS 26_ ERDAG 31_ PEPDK 36_ APRRL 41_ NKRRF 46_ PGLRL 51_ FGHRK 56_ AITKS 61_ GLQHL 66_ APPPP 71_ TPGAP 76_ CSESE 81_ RQIRS 86_ TVDWS 91_ ESATY 96_ GEHIW 101_ FETNV 106_ SGDFC 111_ YVGEQ 116_ YCVAR 121_ MLKSV 126_ SRRKC 131_ AACKI 136_ VVHTP 141_ CIEQL 146_ EKINF 151_ RCKPS 156_ FRESG 161_ SRNVR 166_ EPTFV 171_ RHHWV 176_ HRRRQ 181_ DGKCR 186_ HCGKG 191_ FQQKF 196_ TFHSK 201_ EIVAI 206_ SCSWC 211_ KQAYH 216_ SKVSC 221_ FMLQQ 226_ IEEPC 231_ SLGVH 236_ AAVVI 241_ PPTWI 246_ LRARR 251_ PQNTL 256_ KASKK 261_ KKRAS 266_ FKRKS 271_ SKKGP 276_ EEGRW 281_ RPFII 286_ RPTPS 291_ PLMKP 296_ LLVFV 301_ NPKSG 306_ GNQGA 311_ KIIQS 316_ FLWYL 321_ NPRQV 326_ FDLSQ 331_ GGPKE 336_ ALEMY 341_ RKVHN 346_ LRILA 351_ CGGDG 356_ TVGWI 361_ LSTLD 366_ QLRLK 371_ PPPPV 376_ AILPL 381_ GTGND 386_ LARTL 391_ NWGGG 396_ YTDEP 401_ VSKIL 406_ SHVEE 411_ GNVVQ 416_ LDRWD 421_ LHAEP 426_ NPEAG 431_ PEDRD 436_ EGATD 441_ RLPLD 446_ VFNNY 451_ FSLGF 456_ DAHVT 461_ LEFHE 466_ SREAN 471_ PEKFN 476_ SRFRN 481_ KMFYA 486_ GTAFS 491_ DFLMG 496_ SSKDL 501_ AKHIR 506_ VVCDG 511_ MDLTP 516_ KIQDL 521_ KPQCV 526_ VFLNI 531_ PRYCA 536_ GTMPW 541_ GHPGE 546_ HHDFE 551_ PQRHD 556_ DGYLE 561_ VIGFT 566_ MTSLA 571_ ALQVG 576_ GHGER 581_ LTQCR 586_ EVVLT 591_ TSKAI 596_ PVQVD 601_ GEPCK 606_ LAASR 611_ IRIAL 616_ RNQAT 621_ MVQKA 626_ KRRSA 631_ APLHS 636_ DQQPV 641_ PEQLR 646_ IQVSR 651_ VSMHD 656_ YEALH 661_ YDKEQ 666_ LKEAS 671_ VPLGT 676_ VVVPG 681_ DSDLE 686_ LCRAH 691_ IERLQ 696_ QEPDG 701_ AGAKS 706_ PTCQK 711_ LSPKW 716_ CFLDA 721_ TTASR 726_ FYRID 731_ RAQEH 736_ LNYVT 741_ EIAQD 746_ EIYIL 751_ DPELL 756_ GASAR 761_ PDLPT 766_ PTSPL 771_ PTSPC 776_ SPTPR 781_ SLQGD 786_ AAPPQ 791_ GEELI 796_ EAAKR 801_ NDFCK 806_ LQELH 811_ RAGGD 816_ LMHRD 821_ EQSRT 826_ LLHHA 831_ VSTGS 836_ KDVVR 841_ YLLDH 846_ APPEI 851_ LDAVE 856_ ENGET 861_ CLHQA 866_ AALGQ 871_ RTICH 876_ YIVEA 881_ GASLM 886_ KTDQQ 891_ GDTPR 896_ QRAEK 901_ AQDTE 906_ LAAYL 911_ ENRQH 916_ YQMIQ 921_REDQE
1: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095, PubMed:9159104). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095, PubMed:9159104). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:19744926, PubMed:22108654, PubMed:9159104). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity)
2: Regulates RASGRP1 activity
3: Does not regulate RASGRP1 activity