Melatonin-related receptor (G protein-coupled receptor 50) (H9)
1_MGPTL 6_ AVPTP 11_ YGCIG 16_ CKLPQ 21_ PEYPP 26_ ALIIF 31_ MFCAM 36_ VITIV 41_ VDLIG 46_ NSMVI 51_ LAVTK 56_ NKKLR 61_ NSGNI 66_ FVVSL 71_ SVADM 76_ LVAIY 81_ PYPLM 86_ LHAMS 91_ IGGWD 96_ LSQLQ 101_ CQMVG 106_ FITGL 111_ SVVGS 116_ IFNIV 121_ AIAIN 126_ RYCYI 131_ CHSLQ 136_ YERIF 141_ SVRNT 146_ CIYLV 151_ ITWIM 156_ TVLAV 161_ LPNMY 166_ IGTIE 171_ YDPRT 176_ YTCIF 181_ NYLNN 186_ PVFTV 191_ TIVCI 196_ HFVLP 201_ LLIVG 206_ FCYVR 211_ IWTKV 216_ LAARD 221_ PAGQN 226_ PDNQL 231_ AEVRN 236_ FLTMF 241_ VIFLL 246_ FAVCW 251_ CPINV 256_ LTVLV 261_ AVSPK 266_ EMAGK 271_ IPNWL 276_ YLAAY 281_ FIAYF 286_ NSCLN 291_ AVIYG 296_ LLNEN 301_ FRREY 306_ WTIFH 311_ AMRHP 316_ IIFFS 321_ GLISD 326_ IREMQ 331_ EARTL 336_ ARARA 341_ HARDQ 346_ AREQD 351_ RAHAC 356_ PAVEE 361_ TPMNV 366_ RNVPL 371_ PGDAA 376_ AGHPD 381_ RASGH 386_ PKPHS 391_ RSSSA 396_ YRKSA 401_ STHHK 406_ SVFSH 411_ SKAAS 416_ GHLKP 421_ VSGHS 426_ KPASG 431_ HPKSA 436_ TVYPK 441_ PASVH 446_ FKADS 451_ VHFKG 456_ DSVHF 461_ KPDSV 466_ HFKPA 471_ SSNPK 476_ PITGH 481_ HVSAG 486_ SHSKS 491_ AFSAA 496_ TSHPK 501_ PTTGH 506_ IKPAT 511_ SHAEP 516_ TTADY 521_ PKPAT 526_ TSHPK 531_ PTAAD 536_ NPELS 541_ ASHCP 546_ EIPAI 551_ AHPVS 556_ DDSDL 561_ PESAS 566_ SPAAG 571_ PTKPA 576_ ASQLE 581_ SDTIA 586_ DLPDP 591_ TVVTT 596_ STNDY 601_ HDVVV 606_ IDVED 611_DPDEM
1: G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation (PubMed:21858214). Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483)
2: Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation