Stromal interaction molecule 1
1_MDVCV 6_ RLALW 11_ LLWGL 16_ LLHQG 21_ QSLSH 26_ SHSEK 31_ ATGTS 36_ SGANS 41_ EESTA 46_ AEFCR 51_ IDKPL 56_ CHSED 61_ EKLSF 66_ EAVRN 71_ IHKLM 76_ DDDAN 81_ GDVDV 86_ EESDE 91_ FLRED 96_ LNYHD 101_ PTVKH 106_ STFHG 111_ EDKLI 116_ SVEDL 121_ WKAWK 126_ SSEVY 131_ NWTVD 136_ EVVQW 141_ LITYV 146_ ELPQY 151_ EETFR 156_ KLQLS 161_ GHAMP 166_ RLAVT 171_ NTTMT 176_ GTVLK 181_ MTDRS 186_ HRQKL 191_ QLKAL 196_ DTVLF 201_ GPPLL 206_ TRHNH 211_ LKDFM 216_ LVVSI 221_ VIGVG 226_ GCWFA 231_ YIQNR 236_ YSKEH 241_ MKKMM 246_ KDLEG 251_ LHRAE 256_ QSLHD 261_ LQERL 266_ HKAQE 271_ EHRTV 276_ EVEKV 281_ HLEKK 286_ LRDEI 291_ NLAKQ 296_ EAQRL 301_ KELRE 306_ GTENE 311_ RSRQK 316_ YAEEE 321_ LEQVR 326_ EALRK 331_ AEKEL 336_ ESHSS 341_ WYAPE 346_ ALQKW 351_ LQLTH 356_ EVEVQ 361_ YYNIK 366_ KQNAE 371_ KQLLV 376_ AKEGA 381_ EKIKK 386_ KRNTL 391_ FGTFH 396_ VAHSS 401_ SLDDV 406_ DHKIL 411_ TAKQA 416_ LSEVT 421_ AALRE 426_ RLHRW 431_ QQIEI 436_ LCGFQ 441_ IVNNP 446_ GIHSL 451_ VAALN 456_ IDPSW 461_ MGSTR 466_ PNPAH 471_ FIMTD 476_ DVDDM 481_ DEEIV 486_ SPLSM 491_ QSPSL 496_ QSSVR 501_ QRLTE 506_ PQHGL 511_ GSQRD 516_ LTHSD 521_ SESSL 526_ HMSDR 531_ QRVAP 536_ KPPQM 541_ SRAAD 546_ EALNA 551_ MTSNG 556_ SHRLI 561_ EGVHP 566_ GSLVE 571_ KLPDS 576_ PALAK 581_ KALLA 586_ LNHGL 591_ DKAHS 596_ LMELS 601_ PSAPP 606_ GGSPH 611_ LDSSR 616_ SHSPS 621_ SPDPD 626_ TPSPV 631_ GDSRA 636_ LQASR 641_ NTRIP 646_ HLAGK 651_ KAVAE 656_ EDNGS 661_ IGEET 666_ DSSPG 671_ RKKFP 676_LKIFK
1: Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671)