Sorting nexin-1
1_MASGG 6_ GGCSA 11_ SERLP 16_ PPFPG 21_ LEPES 26_ EGAAG 31_ GSEPE 36_ AGDSD 41_ TEGED 46_ IFTGA 51_ AVVSK 56_ HQSPK 61_ ITTSL 66_ LPINN 71_ GSKEN 76_ GIHEE 81_ QDQEP 86_ QDLFA 91_ DATVE 96_ LSLDS 101_ TQNNQ 106_ KKVLA 111_ KTLIS 116_ LPPQE 121_ ATNSS 126_ KPQPT 131_ YEELE 136_ EEEQE 141_ DQFDL 146_ TVGIT 151_ DPEKI 156_ GDGMN 161_ AYVAY 166_ KVTTQ 171_ TSLPL 176_ FRSKQ 181_ FAVKR 186_ RFSDF 191_ LGLYE 196_ KLSEK 201_ HSQNG 206_ FIVPP 211_ PPEKS 216_ LIGMT 221_ KVKVG 226_ KEDSS 231_ SAEFL 236_ EKRRA 241_ ALERY 246_ LQRIV 251_ NHPTM 256_ LQDPD 261_ VREFL 266_ EKEEL 271_ PRAVG 276_ TQTLS 281_ GAGLL 286_ KMFNK 291_ ATDAV 296_ SKMTI 301_ KMNES 306_ DIWFE 311_ EKLQE 316_ VECEE 321_ QRLRK 326_ LHAVV 331_ ETLVN 336_ HRKEL 341_ ALNTA 346_ QFAKS 351_ LAMLG 356_ SSEDN 361_ TALSR 366_ ALSQL 371_ AEVEE 376_ KIEQL 381_ HQEQA 386_ NNDFF 391_ LLAEL 396_ LSDYI 401_ RLLAI 406_ VRAAF 411_ DQRMK 416_ TWQRW 421_ QDAQA 426_ TLQKK 431_ REAEA 436_ RLLWA 441_ NKPDK 446_ LQQAK 451_ DEILE 456_ WESRV 461_ TQYER 466_ DFERI 471_ STVVR 476_ KEVIR 481_ FEKEK 486_ SKDFK 491_ NHVIK 496_ YLETL 501_ LYSQQ 506_ QLAKY 511_ WEAFL 516_PEAKA
1: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498)