Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1)
1_MALAV 6_ LRVLE 11_ PFPTE 16_ TPPLA 21_ VLLPP 26_ GGPWP 31_ AAELG 36_ LVLAL 41_ RPAGE 46_ SPAGP 51_ ALLVA 56_ ALEGP 61_ DAGTE 66_ EQGPG 71_ PPQLL 76_ VSRAL 81_ LRLLA 86_ LGSGA 91_ WVRAR 96_ AVRRP 101_ PALGW 106_ ALLGT 111_ SLGPG 116_ LGPRV 121_ GPLLV 126_ RRGET 131_ LPVPG 136_ PRVLE 141_ TRPAL 146_ QGLLG 151_ PGTRL 156_ AVTEL 161_ RGRAR 166_ LCPES 171_ GDSSR 176_ PPPPP 181_ VVSSF 186_ AVSGT 191_ VRRLQ 196_ GVLGG 201_ TGDSL 206_ GVSRS 211_ CLRGL 216_ GLFQG 221_ EWVWV 226_ AQARE 231_ SSNTS 236_ QPHLA 241_ RVQVL 246_ EPRWD 251_ LSDRL 256_ GPGSG 261_ PLGEP 266_ LADGL 271_ ALVPA 276_ TLAFN 281_ LGCDP 286_ LEMGE 291_ LRIQR 296_ YLEGS 301_ IAPED 306_ KGSCS 311_ LLPGP 316_ PFARE 321_ LHIEI 326_ VSSPH 331_ YSTNG 336_ NYDGV 341_ LYRHF 346_ QIPRV 351_ VQEGD 356_ VLCVP 361_ TIGQV 366_ EILEG 371_ SPEKL 376_ PRWRE 381_ MFFKV 386_ KKTVG 391_ EAPDG 396_ PASAY 401_ LADTT 406_ HTSLY 411_ MVGST 416_ LSPVP 421_ WLPSE 426_ ESTLW 431_ SSLSP 436_ PGLEA 441_ LVSEL 446_ CAVLK 451_ PRLQP 456_ GGALL 461_ TGTSS 466_ VLLRG 471_ PPGCG 476_ KTTVV 481_ AAACS 486_ HLGLH 491_ LLKVP 496_ CSSLC 501_ AESSG 506_ AVETK 511_ LQAIF 516_ SRARR 521_ CRPAV 526_ LLLTA 531_ VDLLG 536_ RDRDG 541_ LGEDA 546_ RVMAV 551_ LRHLL 556_ LNEDP 561_ LNSCP 566_ PLMVV 571_ ATTSR 576_ AQDLP 581_ ADVQT 586_ AFPHE 591_ LEVPA 596_ LSEGQ 601_ RLSIL 606_ RALTA 611_ HLPLG 616_ QEVNL 621_ AQLAR 626_ RCAGF 631_ VVGDL 636_ YALLT 641_ HSSRA 646_ ACTRI 651_ KNSGL 656_ AGGLT 661_ EEDEG 666_ ELCAA 671_ GFPLL 676_ AEDFG 681_ QALEQ 686_ LQTAH 691_ SQAVG 696_ APKIP 701_ SVSWH 706_ DVGGL 711_ QEVKK 716_ EILET 721_ IQLPL 726_ EHPEL 731_ LSLGL 736_ RRSGL 741_ LLHGP 746_ PGTGK 751_ TLLAK 756_ AVATE 761_ CSLTF 766_ LSVKG 771_ PELIN 776_ MYVGQ 781_ SEENV 786_ REVFA 791_ RARAA 796_ APCII 801_ FFDEL 806_ DSLAP 811_ SRGRS 816_ GDSGG 821_ VMDRV 826_ VSQLL 831_ AELDG 836_ LHSTQ 841_ DVFVI 846_ GATNR 851_ PDLLD 856_ PALLR 861_ PGRFD 866_ KLVFV 871_ GANED 876_ RASQL 881_ RVLSA 886_ ITRKF 891_ KLEPS 896_ VSLVN 901_ VLDCC 906_ PPQLT 911_ GADLY 916_ SLCSD 921_ AMTAA 926_ LKRRV 931_ HDLEE 936_ GLEPG 941_ SSALM 946_ LTMED 951_ LLQAA 956_ ARLQP 961_ SVSEQ 966_ ELLRY 971_KRIQR
1: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772)