Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD)
1_MSREL 6_ APLLL 11_ LLLSI 16_ HSALA 21_ MRICS 26_ FNVRS 31_ FGESK 36_ QEDKN 41_ AMDVI 46_ VKVIK 51_ RCDII 56_ LVMEI 61_ KDSNN 66_ RICPI 71_ LMEKL 76_ NRNSR 81_ RGITY 86_ NYVIS 91_ SRLGR 96_ NTYKE 101_ QYAFL 106_ YKEKL 111_ VSVKR 116_ SYHYH 121_ DYQDG 126_ DADVF 131_ SREPF 136_ VVWFQ 141_ SPHTA 146_ VKDFV 151_ IIPLH 156_ TTPET 161_ SVKEI 166_ DELVE 171_ VYTDV 176_ KHRWK 181_ AENFI 186_ FMGDF 191_ NAGCS 196_ YVPKK 201_ AWKNI 206_ RLRTD 211_ PRFVW 216_ LIGDQ 221_ EDTTV 226_ KKSTN 231_ CAYDR 236_ IVLRG 241_ QEIVS 246_ SVVPK 251_ SNSVF 256_ DFQKA 261_ YKLTE 266_ EEALD 271_ VSDHF 276_ PVEFK 281_ LQSSR 286_ AFTNS 291_ KKSVT 296_LRKKT
1: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:10807908, PubMed:14646506, PubMed:27293190, PubMed:9070308, PubMed:9714828). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)