Cullin-1 (CUL-1)
1_MSSTR 6_ SQNPH 11_ GLKQI 16_ GLDQI 21_ WDDLR 26_ AGIQQ 31_ VYTRQ 36_ SMAKS 41_ RYMEL 46_ YTHVY 51_ NYCTS 56_ VHQSN 61_ QARGA 66_ GVPPS 71_ KSKKG 76_ QTPGG 81_ AQFVG 86_ LELYK 91_ RLKEF 96_ LKNYL 101_ TNLLK 106_ DGEDL 111_ MDESV 116_ LKFYT 121_ QQWED 126_ YRFSS 131_ KVLNG 136_ ICAYL 141_ NRHWV 146_ RRECD 151_ EGRKG 156_ IYEIY 161_ SLALV 166_ TWRDC 171_ LFRPL 176_ NKQVT 181_ NAVLK 186_ LIEKE 191_ RNGET 196_ INTRL 201_ ISGVV 206_ QSYVE 211_ LGLNE 216_ DDAFA 221_ KGPTL 226_ TVYKE 231_ SFESQ 236_ FLADT 241_ ERFYT 246_ RESTE 251_ FLQQN 256_ PVTEY 261_ MKKAE 266_ ARLLE 271_ EQRRV 276_ QVYLH 281_ ESTQD 286_ ELARK 291_ CEQVL 296_ IEKHL 301_ EIFHT 306_ EFQNL 311_ LDADK 316_ NEDLG 321_ RMYNL 326_ VSRIQ 331_ DGLGE 336_ LKKLL 341_ ETHIH 346_ NQGLA 351_ AIEKC 356_ GEAAL 361_ NDPKM 366_ YVQTV 371_ LDVHK 376_ KYNAL 381_ VMSAF 386_ NNDAG 391_ FVAAL 396_ DKACG 401_ RFINN 406_ NAVTK 411_ MAQSS 416_ SKSPE 421_ LLARY 426_ CDSLL 431_ KKSSK 436_ NPEEA 441_ ELEDT 446_ LNQVM 451_ VVFKY 456_ IEDKD 461_ VFQKF 466_ YAKML 471_ AKRLV 476_ HQNSA 481_ SDDAE 486_ ASMIS 491_ KLKQA 496_ CGFEY 501_ TSKLQ 506_ RMFQD 511_ IGVSK 516_ DLNEQ 521_ FKKHL 526_ TNSEP 531_ LDLDF 536_ SIQVL 541_ SSGSW 546_ PFQQS 551_ CTFAL 556_ PSELE 561_ RSYQR 566_ FTAFY 571_ ASRHS 576_ GRKLT 581_ WLYQL 586_ SKGEL 591_ VTNCF 596_ KNRYT 601_ LQAST 606_ FQMAI 611_ LLQYN 616_ TEDAY 621_ TVQQL 626_ TDSTQ 631_ IKMDI 636_ LAQVL 641_ QILLK 646_ SKLLV 651_ LEDEN 656_ ANVDE 661_ VELKP 666_ DTLIK 671_ LYLGY 676_ KNKKL 681_ RVNIN 686_ VPMKT 691_ EQKQE 696_ QETTH 701_ KNIEE 706_ DRKLL 711_ IQAAI 716_ VRIMK 721_ MRKVL 726_ KHQQL 731_ LGEVL 736_ TQLSS 741_ RFKPR 746_ VPVIK 751_ KCIDI 756_ LIEKE 761_ YLERV 766_ DGEKD 771_TYSYL
1: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:22017875, PubMed:22017877, PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1 (PubMed:12609982, PubMed:38326650). The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component (PubMed:38326650). SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25503564, PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Neddylated CUL1-RBX1 ubiquitinates p53/TP53 recruited by Cul7-RING(FBXW8) complex (PubMed:35982156). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). The SCF(FBXO31) protein ligase complex specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress (PubMed:39880951)