Cullin-4B (CUL-4B)
1_MMSQS 6_ SGSGD 11_ GNDDE 16_ ATTSK 21_ DGGFS 26_ SPSPS 31_ AAAAA 36_ QEVRS 41_ ATDGN 46_ TSTTP 51_ PTSAK 56_ KRKLN 61_ SSSSS 66_ SSNSS 71_ NERED 76_ FDSTS 81_ SSSST 86_ PPLQP 91_ RDSAS 96_ PSTSS 101_ FCLGV 106_ SVAAS 111_ SHVPI 116_ QKKLR 121_ FEDTL 126_ EFVGF 131_ DAKMA 136_ EESSS 141_ SSSSS 146_ SPTAA 151_ TSQQQ 156_ QLKNK 161_ SILIS 166_ SVASV 171_ HHANG 176_ LAKSS 181_ TTVSS 186_ FANSK 191_ PGSAK 196_ KLVIK 201_ NFKDK 206_ PKLPE 211_ NYTDE 216_ TWQKL 221_ KEAVE 226_ AIQNS 231_ TSIKY 236_ NLEEL 241_ YQAVE 246_ NLCSY 251_ KISAN 256_ LYKQL 261_ RQICE 266_ DHIKA 271_ QIHQF 276_ REDSL 281_ DSVLF 286_ LKKID 291_ RCWQN 296_ HCRQM 301_ IMIRS 306_ IFLFL 311_ DRTYV 316_ LQNSM 321_ LPSIW 326_ DMGLE 331_ LFRAH 336_ IISDQ 341_ KVQNK 346_ TIDGI 351_ LLLIE 356_ RERNG 361_ EAIDR 366_ SLLRS 371_ LLSML 376_ SDLQI 381_ YQDSF 386_ EQRFL 391_ EETNR 396_ LYAAE 401_ GQKLM 406_ QEREV 411_ PEYLH 416_ HVNKR 421_ LEEEA 426_ DRLIT 431_ YLDQT 436_ TQKSL 441_ IATVE 446_ KQLLG 451_ EHLTA 456_ ILQKG 461_ LNNLL 466_ DENRI 471_ QDLSL 476_ LYQLF 481_ SRVRG 486_ GVQVL 491_ LQQWI 496_ EYIKA 501_ FGSTI 506_ VINPE 511_ KDKTM 516_ VQELL 521_ DFKDK 526_ VDHII 531_ DICFL 536_ KNEKF 541_ INAMK 546_ EAFET 551_ FINKR 556_ PNKPA 561_ ELIAK 566_ YVDSK 571_ LRAGN 576_ KEATD 581_ EELEK 586_ MLDKI 591_ MIIFR 596_ FIYGK 601_ DVFEA 606_ FYKKD 611_ LAKRL 616_ LVGKS 621_ ASVDA 626_ EKSML 631_ SKLKH 636_ ECGAA 641_ FTSKL 646_ EGMFK 651_ DMELS 656_ KDIMI 661_ QFKQY 666_ MQNQN 671_ VPGNI 676_ ELTVN 681_ ILTMG 686_ YWPTY 691_ VPMEV 696_ HLPPE 701_ MVKLQ 706_ EIFKT 711_ FYLGK 716_ HSGRK 721_ LQWQS 726_ TLGHC 731_ VLKAE 736_ FKEGK 741_ KELQV 746_ SLFQT 751_ LVLLM 756_ FNEGE 761_ EFSLE 766_ EIKQA 771_ TGIED 776_ GELRR 781_ TLQSL 786_ ACGKA 791_ RVLAK 796_ NPKGK 801_ DIEDG 806_ DKFIC 811_ NDDFK 816_ HKLFR 821_ IKINQ 826_ IQMKE 831_ TVEEQ 836_ ASTTE 841_ RVFQD 846_ RQYQI 851_ DAAIV 856_ RIMKM 861_ RKTLS 866_ HNLLV 871_ SEVYN 876_ QLKFP 881_ VKPAD 886_ LKKRI 891_ ESLID 896_ RDYME 901_ RDKEN 906_PNQYN
1: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351)