Ras-related protein Rab-31 (Ras-related protein Rab-22B)
1_MAIRE 6_ LKVCL 11_ LGDTG 16_ VGKSS 21_ IVCRF 26_ VQDHF 31_ DHNIS 36_ PTIGA 41_ SFMTK 46_ TVPCG 51_ NELHK 56_ FLIWD 61_ TAGQE 66_ RFHSL 71_ APMYY 76_ RGSAA 81_ AVIVY 86_ DITKQ 91_ DSFYT 96_ LKKWV 101_ KELKE 106_ HGPEN 111_ IVMAI 116_ AGNKC 121_ DLSDI 126_ REVPL 131_ KDAKE 136_ YAESI 141_ GAIVV 146_ ETSAK 151_ NAINI 156_ EELFQ 161_ GISRQ 166_ IPPLD 171_ PHENG 176_ NNGTI 181_ KVEKP 186_TMQAS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis