Ras-related protein Rab-32
1_MAGGG 6_ AGDPG 11_ LGAAA 16_ APAPE 21_ TREHL 26_ FKVLV 31_ IGELG 36_ VGKTS 41_ IIKRY 46_ VHQLF 51_ SQHYR 56_ ATIGV 61_ DFALK 66_ VLNWD 71_ SRTLV 76_ RLQLW 81_ DIAGQ 86_ ERFGN 91_ MTRVY 96_ YKEAV 101_ GAFVV 106_ FDISR 111_ SSTFE 116_ AVLKW 121_ KSDLD 126_ SKVHL 131_ PNGSP 136_ IPAVL 141_ LANKC 146_ DQNKD 151_ SSQSP 156_ SQVDQ 161_ FCKEH 166_ GFAGW 171_ FETSA 176_ KDNIN 181_ IEEAA 186_ RFLVE 191_ KILVN 196_ HQSFP 201_ NEEND 206_ VDKIK 211_ LDQET 216_LRAEN
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736)