5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)
1_MDKLD 6_ ANVSS 11_ EEGFG 16_ SVEKV 21_ VLLTF 26_ LSTVI 31_ LMAIL 36_ GNLLV 41_ MVAVC 46_ WDRQL 51_ RKIKT 56_ NYFIV 61_ SLAFA 66_ DLLVS 71_ VLVMP 76_ FGAIE 81_ LVQDI 86_ WIYGE 91_ VFCLV 96_ RTSLD 101_ VLLTT 106_ ASIFH 111_ LCCIS 116_ LDRYY 121_ AICCQ 126_ PLVYR 131_ NKMTP 136_ LRIAL 141_ MLGGC 146_ WVIPT 151_ FISFL 156_ PIMQG 161_ WNNIG 166_ IIDLI 171_ EKRKF 176_ NQNSN 181_ STYCV 186_ FMVNK 191_ PYAIT 196_ CSVVA 201_ FYIPF 206_ LLMVL 211_ AYYRI 216_ YVTAK 221_ EHAHQ 226_ IQMLQ 231_ RAGAS 236_ SESRP 241_ QSADQ 246_ HSTHR 251_ MRTET 256_ KAAKT 261_ LCIIM 266_ GCFCL 271_ CWAPF 276_ FVTNI 281_ VDPFI 286_ DYTVP 291_ GQVWT 296_ AFLWL 301_ GYINS 306_ GLNPF 311_ LYAFL 316_ NKSFR 321_ RAFLI 326_ ILCCD 331_ DERYR 336_ RPSIL 341_ GQTVP 346_ CSTTT 351_ INGST 356_ HVLRD 361_ AVECG 366_ GQWES 371_ QCHPP 376_ ATSPL 381_VAAQP
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:16102731, PubMed:35714614)