Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
1_MESPG 6_ ESGAG 11_ SPGAP 16_ SPSSF 21_ TTGHL 26_ AREKP 31_ AQDPL 36_ YDVPN 41_ ASGGQ 46_ AGGPQ 51_ RPGRV 56_ VSLRE 61_ RLLLT 66_ RPVWL 71_ QLQAN 76_ AAAAL 81_ HMLRT 86_ EPPGT 91_ FLVRK 96_ SNTRQ 101_ CQALC 106_ MRLPE 111_ ASGPS 116_ FVSSH 121_ YILES 126_ PGGVS 131_ LEGSE 136_ LMFPD 141_ LVQLI 146_ CAYCH 151_ TRDIL 156_ LLPLQ 161_ LPRAI 166_ HHAAT 171_ HKELE 176_ AISHL 181_ GIEFW 186_ SSSLN 191_ IKAQR 196_ GPAGG 201_ PVLPQ 206_ LKARS 211_ PQELD 216_ QGTGA 221_ ALCFF 226_ NPLFP 231_ GDLGP 236_ TKREK 241_ FKRSF 246_ KVRVS 251_ TETSS 256_ PLSPP 261_ AVPPP 266_ PVPVL 271_ PGAVP 276_ SQTER 281_ LPPCQ 286_ LLRRE 291_ SSVGY 296_ RVPAG 301_ SGPSL 306_ PPMPS 311_ LQEVD 316_ CGSPS 321_ SSEEE 326_ GVPGS 331_ RGSPA 336_ TSPHL 341_ GRRRP 346_ LLRSM 351_ SAAFC 356_ SLLAP 361_ ERQVG 366_ RAAAA 371_ LMQDR 376_ HTAAG 381_ QLVQD 386_ LLTQV 391_ RAGPE 396_ PQELQ 401_ GIRQA 406_ LSRAR 411_ AMLSA 416_ ELGPE 421_ KLLSP 426_ KRLEH 431_ VLEKS 436_ LHCSV 441_ LKPLR 446_ PILAA 451_ RLRRR 456_ LAADG 461_ SLGRL 466_ AEGLR 471_ LARAQ 476_ GPGAF 481_ GSHLS 486_ LPSPV 491_ ELEQV 496_ RQKLL 501_ QLLRT 506_ YSPSA 511_ QVKRL 516_ LQACK 521_ LLYMA 526_ LRTQE 531_ GEGAG 536_ ADEFL 541_ PLLSL 546_ VLAHC 551_ DLPEL 556_ LLEAE 561_ YMSEL 566_ LEPSL 571_ LTGEG 576_ GYYLT 581_ SLSAS 586_ LALLS 591_ GLGQA 596_ HTLPL 601_ SPVQE 606_ LRRSL 611_ SLWEQ 616_ RRLPA 621_ THCFQ 626_ HLLRV 631_ AYQDP 636_ SSGCT 641_ SKTLA 646_ VPPEA 651_ SIATL 656_ NQLCA 661_ TKFRV 666_ TQPNT 671_ FGLFL 676_ YKEQG 681_ YHRLP 686_ PGALA 691_ HRLPT 696_ TGYLV 701_ YRRAE 706_ WPETQ 711_ GAVTE 716_ EEGSG 721_ QSEAR 726_ SRGEE 731_ QGCQG 736_ DGDAG 741_ VKASP 746_ RDIRE 751_ QSETT 756_ AEGGQ 761_ GQAQE 766_ GPAQP 771_ GEPEA 776_EGSRA
1: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis