Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]
1_MAGAR 6_ SRDPW 11_ GASGI 16_ CYLFG 21_ SLLVE 26_ LLFSR 31_ AVAFN 36_ LDVMG 41_ ALRKE 46_ GEPGS 51_ LFGFS 56_ VALHR 61_ QLQPR 66_ PQSWL 71_ LVGAP 76_ QALAL 81_ PGQQA 86_ NRTGG 91_ LFACP 96_ LSLEE 101_ TDCYR 106_ VDIDQ 111_ GADMQ 116_ KESKE 121_ NQWLG 126_ VSVRS 131_ QGPGG 136_ KIVTC 141_ AHRYE 146_ ARQRV 151_ DQILE 156_ TRDMI 161_ GRCFV 166_ LSQDL 171_ AIRDE 176_ LDGGE 181_ WKFCE 186_ GRPQG 191_ HEQFG 196_ FCQQG 201_ TAAAF 206_ SPDSH 211_ YLLFG 216_ APGTY 221_ NWKGT 226_ ARVEL 231_ CAQGS 236_ ADLAH 241_ LDDGP 246_ YEAGG 251_ EKEQD 256_ PRLIP 261_ VPANS 266_ YFGLL 271_ FVTNI 276_ DSSDP 281_ DQLVY 286_ KTLDP 291_ ADRLP 296_ GPAGD 301_ LALNS 306_ YLGFS 311_ IDSGK 316_ GLVRA 321_ EELSF 326_ VAGAP 331_ RANHK 336_ GAVVI 341_ LRKDS 346_ ASRLV 351_ PEVML 356_ SGERL 361_ TSGFG 366_ YSLAV 371_ ADLNS 376_ DGWPD 381_ LIVGA 386_ PYFFE 391_ RQEEL 396_ GGAVY 401_ VYLNQ 406_ GGHWA 411_ GISPL 416_ RLCGS 421_ PDSMF 426_ GISLA 431_ VLGDL 436_ NQDGF 441_ PDIAV 446_ GAPFD 451_ GDGKV 456_ FIYHG 461_ SSLGV 466_ VAKPS 471_ QVLEG 476_ EAVGI 481_ KSFGY 486_ SLSGS 491_ LDMDG 496_ NQYPD 501_ LLVGS 506_ LADTA 511_ VLFRA 516_ RPILH 521_ VSHEV 526_ SIAPR 531_ SIDLE 536_ QPNCA 541_ GGHSV 546_ CVDLR 551_ VCFSY 556_ IAVPS 561_ SYSPT 566_ VALDY 571_ VLDAD 576_ TDRRL 581_ RGQVP 586_ RVTFL 591_ SRNLE 596_ EPKHQ 601_ ASGTV 606_ WLKHQ 611_ HDRVC 616_ GDAMF 621_ QLQEN 626_ VKDKL 631_ RAIVV 636_ TLSYS 641_ LQTPR 646_ LRRQA 651_ PGQGL 656_ PPVAP 661_ ILNAH 666_ QPSTQ 671_ RAEIH 676_ FLKQG 681_ CGEDK 686_ ICQSN 691_ LQLVR 696_ ARFCT 701_ RVSDT 706_ EFQPL 711_ PMDVD 716_ GTTAL 721_ FALSG 726_ QPVIG 731_ LELMV 736_ TNLPS 741_ DPAQP 746_ QADGD 751_ DAHEA 756_ QLLVM 761_ LPDSL 766_ HYSGV 771_ RALDP 776_ AEKPL 781_ CLSNE 786_ NASHV 791_ ECELG 796_ NPMKR 801_ GAQVT 806_ FYLIL 811_ STSGI 816_ SIETT 821_ ELEVE 826_ LLLAT 831_ ISEQE 836_ LHPVS 841_ ARARV 846_ FIELP 851_ LSIAG 856_ MAIPQ 861_ QLFFS 866_ GVVRG 871_ ERAMQ 876_ SERDV 881_ GSKVK 886_ YEVTV 891_ SNQGQ 896_ SLRTL 901_ GSAFL 906_ NIMWP 911_ HEIAN 916_ GKWLL 921_ YPMQV 926_ ELEGG 931_ QGPGQ 936_ KGLCS 941_ PRPNI 946_ LHLDV 951_ DSRDR 956_ RRREL 961_ EPPEQ 966_ QEPGE 971_ RQEPS 976_ MSWWP 981_ VSSAE 986_ KKKNI 991_ TLDCA 996_ RGTAN 1001_ CVVFS 1006_ CPLYS 1011_ FDRAA 1016_ VLHVW 1021_ GRLWN 1026_ STFLE 1031_ EYSAV 1036_ KSLEV 1041_ IVRAN 1046_ ITVKS 1051_ SIKNL 1056_ MLRDA 1061_ STVIP 1066_ VMVYL 1071_ DPMAV 1076_ VAEGV 1081_ PWWVI 1086_ LLAVL 1091_ AGLLV 1096_ LALLV 1101_ LLLWK 1106_ MGFFK 1111_ RAKHP 1116_ EATVP 1121_ QYHAV 1126_ KIPRE 1131_ DRQQF 1136_ KEEKT 1141_ GTILR 1146_ NNWGS 1151_ PRREG 1156_ PDAHP 1161_ ILAAD 1166_ GHPEL 1171_ GPDGH 1176_PGPGT
1: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells