Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)
1_MEPSS 6_ PQDEG 11_ LRKKQ 16_ PKKPV 21_ PEILP 26_ RPPRA 31_ LFCLT 36_ LENPL 41_ RKACI 46_ SIVEW 51_ KPFET 56_ IILLT 61_ IFANC 66_ VALAV 71_ YLPMP 76_ EDDNN 81_ SLNLG 86_ LEKLE 91_ YFFLI 96_ VFSIE 101_ AAMKI 106_ IAYGF 111_ LFHQD 116_ AYLRS 121_ GWNVL 126_ DFTIV 131_ FLGVF 136_ TVILE 141_ QVNVI 146_ QSHTA 151_ PMSSK 156_ GAGLD 161_ VKALR 166_ AFRVL 171_ RPLRL 176_ VSGVP 181_ SLQVV 186_ LNSIF 191_ KAMLP 196_ LFHIA 201_ LLVLF 206_ MVIIY 211_ AIIGL 216_ ELFKG 221_ KMHKT 226_ CYFIG 231_ TDIVA 236_ TVENE 241_ EPSPC 246_ ARTGS 251_ GRRCT 256_ INGSE 261_ CRGGW 266_ PGPNH 271_ GITHF 276_ DNFGF 281_ SMLTV 286_ YQCIT 291_ MEGWT 296_ DVLYW 301_ VNDAI 306_ GNEWP 311_ WIYFV 316_ TLILL 321_ GSFFI 326_ LNLVL 331_ GVLSG 336_ EFTKE 341_ REKAK 346_ SRGTF 351_ QKLRE 356_ KQQLD 361_ EDLRG 366_ YMSWI 371_ TQGEV 376_ MDVED 381_ FREGK 386_ LSLDE 391_ GGSDT 396_ ESLYE 401_ IAGLN 406_ KIIQF 411_ IRHWR 416_ QWNRI 421_ FRWKC 426_ HDIVK 431_ SKVFY 436_ WLVIL 441_ IVALN 446_ TLSIA 451_ SEHHN 456_ QPLWL 461_ TRLQD 466_ IANRV 471_ LLSLF 476_ TTEML 481_ MKMYG 486_ LGLRQ 491_ YFMSI 496_ FNRFD 501_ CFVVC 506_ SGILE 511_ ILLVE 516_ SGAMT 521_ PLGIS 526_ VLRCI 531_ RLLRI 536_ FKITK 541_ YWTSL 546_ SNLVA 551_ SLLNS 556_ IRSIA 561_ SLLLL 566_ LFLFI 571_ VIFAL 576_ LGMQL 581_ FGGRY 586_ DFEDT 591_ EVRRS 596_ NFDNF 601_ PQALI 606_ SVFQV 611_ LTGED 616_ WTSMM 621_ YNGIM 626_ AYGGP 631_ SYPGM 636_ LVCIY 641_ FIILF 646_ VCGNY 651_ ILLNV 656_ FLAIA 661_ VDNLA 666_ EAESL 671_ TSAQK 676_ AKAEE 681_ KKRRK 686_ MSKGL 691_ PDKSE 696_ EEKST 701_ MAKKL 706_ EQKPK 711_ GEGIP 716_ TTAKL 721_ KIDEF 726_ ESNVN 731_ EVKDP 736_ YPSAD 741_ FPGDD 746_ EEDEP 751_ EIPLS 756_ PRPRP 761_ LAELQ 766_ LKEKA 771_ VPIPE 776_ ASSFF 781_ IFSPT 786_ NKIRV 791_ LCHRI 796_ VNATW 801_ FTNFI 806_ LLFIL 811_ LSSAA 816_ LAAED 821_ PIRAD 826_ SMRNQ 831_ ILKHF 836_ DIGFT 841_ SVFTV 846_ EIVLK 851_ MTTYG 856_ AFLHK 861_ GSFCR 866_ NYFNM 871_ LDLLV 876_ VAVSL 881_ ISMGL 886_ ESSAI 891_ SVVKI 896_ LRVLR 901_ VLRPL 906_ RAINR 911_ AKGLK 916_ HVVQC 921_ MFVAI 926_ STIGN 931_ IVLVT 936_ TLLQF 941_ MFACI 946_ GVQLF 951_ KGKFF 956_ RCTDL 961_ SKMTE 966_ EECRG 971_ YYYVY 976_ KDGDP 981_ MQIEL 986_ RHREW 991_ VHSDF 996_ HFDNV 1001_ LSAMM 1006_ SLFTV 1011_ STFEG 1016_ WPQLL 1021_ YKAID 1026_ SNAED 1031_ VGPIY 1036_ NNRVE 1041_ MAIFF 1046_ IIYII 1051_ LIAFF 1056_ MMNIF 1061_ VGFVI 1066_ VTFQE 1071_ QGETE 1076_ YKNCE 1081_ LDKNQ 1086_ RQCVQ 1091_ YALKA 1096_ RPLRC 1101_ YIPKN 1106_ PYQYQ 1111_ VWYIV 1116_ TSSYF 1121_ EYLMF 1126_ ALIML 1131_ NTICL 1136_ GMQHY 1141_ NQSEQ 1146_ MNHIS 1151_ DILNV 1156_ AFTII 1161_ FTLEM 1166_ ILKLM 1171_ AFKAR 1176_ GYFGD 1181_ PWNVF 1186_ DFLIV 1191_ IGSII 1196_ DVILS 1201_ EIDTF 1206_ LASSG 1211_ GLYCL 1216_ GGGCG 1221_ NVDPD 1226_ ESARI 1231_ SSAFF 1236_ RLFRV 1241_ MRLIK 1246_ LLSRA 1251_ EGVRT 1256_ LLWTF 1261_ IKSFQ 1266_ ALPYV 1271_ ALLIV 1276_ MLFFI 1281_ YAVIG 1286_ MQMFG 1291_ KIALV 1296_ DGTQI 1301_ NRNNN 1306_ FQTFP 1311_ QAVLL 1316_ LFRCA 1321_ TGEAW 1326_ QEILL 1331_ ACSYG 1336_ KLCDP 1341_ ESDYA 1346_ PGEEY 1351_ TCGTN 1356_ FAYYY 1361_ FISFY 1366_ MLCAF 1371_ LVINL 1376_ FVAVI 1381_ MDNFD 1386_ YLTRD 1391_ WSILG 1396_ PHHLD 1401_ EFKAI 1406_ WAEYD 1411_ PEAKG 1416_ RIKHL 1421_ DVVTL 1426_ LRRIQ 1431_ PPLGF 1436_ GKFCP 1441_ HRVAC 1446_ KRLVG 1451_ MNMPL 1456_ NSDGT 1461_ VTFNA 1466_ TLFAL 1471_ VRTAL 1476_ KIKTE 1481_ GNFEQ 1486_ ANEEL 1491_ RAIIK 1496_ KIWKR 1501_ TSMKL 1506_ LDQVI 1511_ PPIGD 1516_ DEVTV 1521_ GKFYA 1526_ TFLIQ 1531_ EHFRK 1536_ FMKRQ 1541_ EEYYG 1546_ YRPKK 1551_ DIVQI 1556_ QAGLR 1561_ TIEEE 1566_ AAPEI 1571_ CRTVS 1576_ GDLAA 1581_ EEELE 1586_ RAMVE 1591_ AAMEE 1596_ GIFRR 1601_ TGGLF 1606_ GQVDN 1611_ FLERT 1616_ NSLPP 1621_ VMANQ 1626_ RPLQF 1631_ AEIEM 1636_ EEMES 1641_ PVFLE 1646_ DFPQD 1651_ PRTNP 1656_ LARAN 1661_ TNNAN 1666_ ANVAY 1671_ GNSNH 1676_ SNSHV 1681_ FSSVH 1686_ YEREF 1691_ PEETE 1696_ TPATR 1701_ GRALG 1706_ QPCRV 1711_ LGPHS 1716_ KPCVE 1721_ MLKGL 1726_ LTQRA 1731_ MPRGQ 1736_ APPAP 1741_ CQCPR 1746_ VESSM 1751_ PEDRK 1756_ SSTPG 1761_ SLHEE 1766_ TPHSR 1771_ STREN 1776_ TSRCS 1781_ APATA 1786_ LLIQK 1791_ ALVRG 1796_ GLGTL 1801_ AADAN 1806_ FIMAT 1811_ GQALA 1816_ DACQM 1821_ EPEEV 1826_ EIMAT 1831_ ELLKG 1836_ REAPE 1841_ GMASS 1846_ LGCLN 1851_ LGSSL 1856_ GSLDQ 1861_ HQGSQ 1866_ETLIP
1: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group