CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
1_MESKG 6_ ASSCR 11_ LLFCL 16_ LISAT 21_ VFRPG 26_ LGWYT 31_ VNSAY 36_ GDTII 41_ IPCRL 46_ DVPQN 51_ LMFGK 56_ WKYEK 61_ PDGSP 66_ VFIAF 71_ RSSTK 76_ KSVQY 81_ DDVPE 86_ YKDRL 91_ NLSEN 96_ YTLSI 101_ SNARI 106_ SDEKR 111_ FVCML 116_ VTEDN 121_ VFEAP 126_ TIVKV 131_ FKQPS 136_ KPEIV 141_ SKALF 146_ LETEQ 151_ LKKLG 156_ DCISE 161_ DSYPD 166_ GNITW 171_ YRNGK 176_ VLHPL 181_ EGAVV 186_ IIFKK 191_ EMDPV 196_ TQLYT 201_ MTSTL 206_ EYKTT 211_ KADIQ 216_ MPFTC 221_ SVTYY 226_ GPSGQ 231_ KTIHS 236_ EQAVF 241_ DIYYP 246_ TEQVT 251_ IQVLP 256_ PKNAI 261_ KEGDN 266_ ITLKC 271_ LGNGN 276_ PPPEE 281_ FLFYL 286_ PGQPE 291_ GIRSS 296_ NTYTL 301_ TDVRR 306_ NATGD 311_ YKCSL 316_ IDKKS 321_ MIAST 326_ AITVH 331_ YLDLS 336_ LNPSG 341_ EVTRQ 346_ IGDAL 351_ PVSCT 356_ ISASR 361_ NATVV 366_ WMKDN 371_ IRLRS 376_ SPSFS 381_ SLHYQ 386_ DAGNY 391_ VCETA 396_ LQEVE 401_ GLKKR 406_ ESLTL 411_ IVEGK 416_ PQIKM 421_ TKKTD 426_ PSGLS 431_ KTIIC 436_ HVEGF 441_ PKPAI 446_ QWTIT 451_ GSGSV 456_ INQTE 461_ ESPYI 466_ NGRYY 471_ SKIII 476_ SPEEN 481_ VTLTC 486_ TAENQ 491_ LERTV 496_ NSLNV 501_ SAISI 506_ PEHDE 511_ ADEIS 516_ DENRE 521_ KVNDQ 526_ AKLIV 531_ GIVVG 536_ LLLAA 541_ LVAGV 546_ VYWLY 551_ MKKSK 556_ TASKH 561_ VNKDL 566_ GNMEE 571_ NKKLE 576_ENNHK
1: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)
2: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation