Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
1_MRIPV 6_ DPSTS 11_ RRFTP 16_ PSPAF 21_ PCGGG 26_ GGKMG 31_ ENSGA 36_ LSAQA 41_ AVGPG 46_ GRARP 51_ EVRSM 56_ VDVLA 61_ DHAGE 66_ LVRTD 71_ SPNFL 76_ CSVLP 81_ SHWRC 86_ NKTLP 91_ VAFKV 96_ VALGD 101_ VPDGT 106_ VVTVM 111_ AGNDE 116_ NYSAE 121_ LRNAS 126_ AVMKN 131_ QVARF 136_ NDLRF 141_ VGRSG 146_ RGKSF 151_ TLTIT 156_ VFTNP 161_ TQVAT 166_ YHRAI 171_ KVTVD 176_ GPREP 181_ RRHRQ 186_ KLEDQ 191_ TKPFP 196_ DRFGD 201_ LERLR 206_ MRVTP 211_ STPSP 216_ RGSLS 221_ TTSHF 226_ SSQPQ 231_ TPIQG 236_ TSELN 241_ PFSDP 246_ RQFDR 251_ SFPTL 256_ PTLTE 261_ SRFPD 266_ PRMHY 271_ PGAMS 276_ AAFPY 281_ SATPS 286_ GTSIS 291_ SLSVA 296_ GMPAT 301_ SRFHH 306_ TYLPP 311_ PYPGA 316_ PQNQS 321_ GPFQA 326_ NPSPY 331_ HLYYG 336_ TSSGS 341_ YQFSM 346_ VAGSS 351_ SGGDR 356_ SPTRM 361_ LASCT 366_ SSAAS 371_ VAAGN 376_ LMNPS 381_ LGGQS 386_ DGVEA 391_ DGSHS 396_ NSPTA 401_ LSTPG 406_RMDEA
1: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity)