Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)
1_MPGEA 6_ TETVP 11_ ATEQE 16_ LPQPQ 21_ AETGS 26_ GTESD 31_ SDESV 36_ PELEE 41_ QDSTQ 46_ ATTQQ 51_ AQLAA 56_ AAEID 61_ EEPVS 66_ KAKQS 71_ RSEKK 76_ ARKAM 81_ SKLGL 86_ RQVTG 91_ VTRVT 96_ IRKSK 101_ NILFV 106_ ITKPD 111_ VYKSP 116_ ASDTY 121_ IVFGE 126_ AKIED 131_ LSQQA 136_ QLAAA 141_ EKFKV 146_ QGEAV 151_ SNIQE 156_ NTQTP 161_ TVQEE 166_ SEEEE 171_ VDETG 176_ VEVKD 181_ IELVM 186_ SQANV 191_ SRAKA 196_ VRALK 201_ NNSND 206_IVNAI
1: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters