THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)
1_MSSES 6_ SKKRK 11_ PKVIR 16_ SDGAP 21_ AEGKR 26_ NRSDT 31_ EQEGK 36_ YYSEE 41_ AEVDL 46_ RDPGR 51_ DYELY 56_ KYTCQ 61_ ELQRL 66_ MAEIQ 71_ DLKSR 76_ GGKDV 81_ AIEIE 86_ ERRIQ 91_ SCVHF 96_ MTLKK 101_ LNRLA 106_ HIRLK 111_ KGRDQ 116_ THEAK 121_ QKVDA 126_ YHLQL 131_ QNLLY 136_ EVMHL 141_ QKEIT 146_ KCLEF 151_ KSKHE 156_ EIDLV 161_ SLEEF 166_ YKEAP 171_ PDISK 176_ AEVTM 181_ GDPHQ 186_ QTLAR 191_ LDWEL 196_ EQRKR 201_ LAEKY 206_ RECLS 211_ NKEKI 216_ LKEIE 221_ VKKEY 226_ LSSLQ 231_ PRLNS 236_ IMQAS 241_ LPVQE 246_ YLFMP 251_ FDQAH 256_ KQYET 261_ ARHLP 266_ PPLYV 271_ LFVQA 276_ TAYGQ 281_ ACDKT 286_ LSVAI 291_ EGSVD 296_ EAKAL 301_ FKPPE 306_ DSQDD 311_ ESDSD 316_ AEEEQ 321_ TTKRR 326_ RPTLG 331_ VQLDD 336_ KRKEM 341_ LKRHP 346_ LSVML 351_ DLKCK 356_ DDSVL 361_ HLTFY 366_ YLMNL 371_ NIMTV 376_ KAKVT 381_ TAMEL 386_ ITPIS 391_ AGDLL 396_ SPDSV 401_ LSCLY 406_ PGDHG 411_ KKTPN 416_ PANQY 421_ QFDKV 426_ GILTL 431_ SDYVL 436_ ELGHP 441_ YLWVQ 446_ KLGGL 451_ HFPKE 456_ QPQQT 461_ VIADH 466_ SLSAS 471_ HMETT 476_ MKLLK 481_ TRVQS 486_ RLALH 491_ KQFAS 496_ LEHGI 501_ VPVTS 506_ DCQYL 511_ FPAKV 516_ VSRLV 521_ KWVTV 526_ AHEDY 531_ MELHF 536_ TKDIV 541_ DAGLA 546_ GDTNL 551_ YYMAL 556_ IERGT 561_ AKLQA 566_ AVVLN 571_ PGYSS 576_ IPPVF 581_ QLCLN 586_ WKGEK 591_ TNSND 596_ DNIRA 601_ MEGEV 606_ NVCYK 611_ ELCGP 616_ WPSHQ 621_ LLTNQ 626_ LQRLC 631_ VLLDV 636_ YLETE 641_ SHDDS 646_ VEGPK 651_ EFPQE 656_ KMCLR 661_ LFRGP 666_ SRMKP 671_ FKYNH 676_PQGFF
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434)
2: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development
3: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production