Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1)
1_MNTFQ 6_ DQSGS 11_ SSNRE 16_ PLLRC 21_ SDARR 26_ DLELA 31_ IGGVL 36_ RAEQQ 41_ IKDNL 46_ REVKA 51_ QIHSC 56_ ISRHL 61_ ECLRS 66_ REVWL 71_ YEQVD 76_ LIYQL 81_ KEETL 86_ QQQAQ 91_ QLYSL 96_ LGQFN 101_ CLTHQ 106_ LECTQ 111_ NKDLA 116_ NQVSV 121_ CLERL 126_ GSLTL 131_ KPEDS 136_ TVLLF 141_ EADTI 146_ TLRQT 151_ ITTFG 156_ SLKTI 161_ QIPEH 166_ LMAHA 171_ SSANI 176_ GPFLE 181_ KRGCI 186_ SMPEQ 191_ KSASG 196_ IVAVP 201_ FSEWL 206_ LGSKP 211_ ASGYQ 216_ APYIP 221_ STDPQ 226_ DWLTQ 231_ KQTLE 236_ NSQTS 241_ SRACN 246_ FFNNV 251_ GGNLK 256_ GLENW 261_ LLKSE 266_ KSSYQ 271_ KCNSH 276_ STTSS 281_ FSIEM 286_ EKVGD 291_ QELPD 296_ QDEMD 301_ LSDWL 306_ VTPQE 311_ SHKLR 316_ KPENG 321_ SRETS 326_ EKFKL 331_ LFQSY 336_ NVNDW 341_ LVKTD 346_ SCTNC 351_ QGNQP 356_ KGVEI 361_ ENLGN 366_ LKCLN 371_ DHLEA 376_ KKPLS 381_ TPSMV 386_ TEDWL 391_ VQNHQ 396_ DPCKV 401_ EEVCR 406_ ANEPC 411_ TSFAE 416_ CVCDE 421_ NCEKE 426_ ALYKW 431_ LLKKE 436_ GKDKN 441_ GMPVE 446_ PKPEP 451_ EKHKD 456_ SLNMW 461_ LCPRK 466_ EVIEQ 471_ TKAPK 476_ AMTPS 481_ RIADS 486_ FQVIK 491_ NSPLS 496_ EWLIR 501_ PPYKE 506_ GSPKE 511_ VPGTE 516_ DRAGK 521_ QKFKS 526_ PMNTS 531_ WCSFN 536_ TADWV 541_ LPGKK 546_ MGNLS 551_ QLSSG 556_ EDKWL 561_ LRKKA 566_ QEVLL 571_ NSPLQ 576_ EEHNF 581_ PPDHY 586_ GLPAV 591_ CDLFA 596_ CMQLK 601_ VDKEK 606_WLYRT
1: Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095)