Gene name: PMAIP1

Uniprot entry:

Q13794

Protein names:

Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)

Protein sequence:

1_MPGKK 6_ ARKNA 11_ QPSPA 16_ RAPAE 21_ LEVEC 26_ ATQLR 31_ RFGDK 36_ LNFRQ 41_ KLLNL 46_ISKLF

Protein annotations

Protein functions:

1: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1