Integrin alpha-9 (Integrin alpha-RLC)
1_MGGPA 6_ APRGA 11_ GRLRA 16_ LLLAL 21_ VVAGI 26_ PAGAY 31_ NLDPQ 36_ RPVHF 41_ QGPAD 46_ SFFGY 51_ AVLEH 56_ FHDNT 61_ RWVLV 66_ GAPKA 71_ DSKYS 76_ PSVKS 81_ PGAVF 86_ KCRVH 91_ TNPDR 96_ RCTEL 101_ DMARG 106_ KNRGT 111_ SCGKT 116_ CREDR 121_ DDEWM 126_ GVSLA 131_ RQPKA 136_ DGRVL 141_ ACAHR 146_ WKNIY 151_ YEADH 156_ ILPHG 161_ FCYII 166_ PSNLQ 171_ AKGRT 176_ LIPCY 181_ EEYKK 186_ KYGEE 191_ HGSCQ 196_ AGIAG 201_ FFTEE 206_ LVVMG 211_ APGSF 216_ YWAGT 221_ IKVLN 226_ LTDNT 231_ YLKLN 236_ DEVIM 241_ NRRYT 246_ YLGYA 251_ VTAGH 256_ FSHPS 261_ TIDVV 266_ GGAPQ 271_ DKGIG 276_ KVYIF 281_ RADRR 286_ SGTLI 291_ KIFQA 296_ SGKKM 301_ GSYFG 306_ SSLCA 311_ VDLNG 316_ DGLSD 321_ LLVGA 326_ PMFSE 331_ IRDEG 336_ QVTVY 341_ INRGN 346_ GALEE 351_ QLALT 356_ GDGAY 361_ NAHFG 366_ ESIAS 371_ LDDLD 376_ NDGFP 381_ DVAIG 386_ APKED 391_ DFAGA 396_ VYIYH 401_ GDAGG 406_ IVPQY 411_ SMKLS 416_ GQKIN 421_ PVLRM 426_ FGQSI 431_ SGGID 436_ MDGNG 441_ YPDVT 446_ VGAFM 451_ SDSVV 456_ LLRAR 461_ PVITV 466_ DVSIF 471_ LPGSI 476_ NITAP 481_ QCHDG 486_ QQPVN 491_ CLNVT 496_ TCFSF 501_ HGKHV 506_ PGEIG 511_ LNYVL 516_ MADVA 521_ KKEKG 526_ QMPRV 531_ YFVLL 536_ GETMG 541_ QVTEK 546_ LQLTY 551_ MEETC 556_ RHYVA 561_ HVKRR 566_ VQDVI 571_ SPIVF 576_ EAAYS 581_ LSEHV 586_ TGEEE 591_ RELPP 596_ LTPVL 601_ RWKKG 606_ QKIAQ 611_ KNQTV 616_ FERNC 621_ RSEDC 626_ AADLQ 631_ LQGKL 636_ LLSSM 641_ DEKTL 646_ YLALG 651_ AVKNI 656_ SLNIS 661_ ISNLG 666_ DDAYD 671_ ANVSF 676_ NVSRE 681_ LFFIN 686_ MWQKE 691_ EMGIS 696_ CELLE 701_ SDFLK 706_ CSVGF 711_ PFMRS 716_ KSKYE 721_ FSVIF 726_ DTSHL 731_ SGEEE 736_ VLSFI 741_ VTAQS 746_ GNTER 751_ SESLH 756_ DNTLV 761_ LMVPL 766_ MHEVD 771_ TSITG 776_ IMSPT 781_ SFVYG 786_ ESVDA 791_ ANFIQ 796_ LDDLE 801_ CHFQP 806_ INITL 811_ QVYNT 816_ GPSTL 821_ PGSSV 826_ SISFP 831_ NRLSS 836_ GGAEM 841_ FHVQE 846_ MVVGQ 851_ EKGNC 856_ SFQKN 861_ PTPCI 866_ IPQEQ 871_ ENIFH 876_ TIFAF 881_ FTKSG 886_ RKVLD 891_ CEKPG 896_ ISCLT 901_ AHCNF 906_ SALAK 911_ EESRT 916_ IDIYM 921_ LLNTE 926_ ILKKD 931_ SSSVI 936_ QFMSR 941_ AKVKV 946_ DPALR 951_ VVEIA 956_ HGNPE 961_ EVTVV 966_ FEALH 971_ NLEPR 976_ GYVVG 981_ WIIAI 986_ SLLVG 991_ ILIFL 996_ LLAVL 1001_ LWKMG 1006_ FFRRR 1011_ YKEII 1016_ EAEKN 1021_ RKENE 1026_DSWDW
1: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072)