Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD)
1_MARRS 6_ SFQSC 11_ QIISL 16_ FTFAV 21_ GVNIC 26_ LGFTA 31_ HRIKR 36_ AEGWE 41_ EGPPT 46_ VLSDS 51_ PWTNI 56_ SGSCK 61_ GRCFE 66_ LQEAG 71_ PPDCR 76_ CDNLC 81_ KSYTS 86_ CCHDF 91_ DELCL 96_ KTARG 101_ WECTK 106_ DRCGE 111_ VRNEE 116_ NACHC 121_ SEDCL 126_ ARGDC 131_ CTNYQ 136_ VVCKG 141_ ESHWV 146_ DDDCE 151_ EIKAA 156_ ECPAG 161_ FVRPP 166_ LIIFS 171_ VDGFR 176_ ASYMK 181_ KGSKV 186_ MPNIE 191_ KLRSC 196_ GTHSP 201_ YMRPV 206_ YPTKT 211_ FPNLY 216_ TLATG 221_ LYPES 226_ HGIVG 231_ NSMYD 236_ PVFDA 241_ TFHLR 246_ GREKF 251_ NHRWW 256_ GGQPL 261_ WITAT 266_ KQGVK 271_ AGTFF 276_ WSVVI 281_ PHERR 286_ ILTIL 291_ QWLTL 296_ PDHER 301_ PSVYA 306_ FYSEQ 311_ PDFSG 316_ HKYGP 321_ FGPEM 326_ TNPLR 331_ EIDKI 336_ VGQLM 341_ DGLKQ 346_ LKLHR 351_ CVNVI 356_ FVGDH 361_ GMEDV 366_ TCDRT 371_ EFLSN 376_ YLTNV 381_ DDITL 386_ VPGTL 391_ GRIRS 396_ KFSNN 401_ AKYDP 406_ KAIIA 411_ NLTCK 416_ KPDQH 421_ FKPYL 426_ KQHLP 431_ KRLHY 436_ ANNRR 441_ IEDIH 446_ LLVER 451_ RWHVA 456_ RKPLD 461_ VYKKP 466_ SGKCF 471_ FQGDH 476_ GFDNK 481_ VNSMQ 486_ TVFVG 491_ YGSTF 496_ KYKTK 501_ VPPFE 506_ NIELY 511_ NVMCD 516_ LLGLK 521_ PAPNN 526_ GTHGS 531_ LNHLL 536_ RTNTF 541_ RPTMP 546_ EEVTR 551_ PNYPG 556_ IMYLQ 561_ SDFDL 566_ GCTCD 571_ DKVEP 576_ KNKLD 581_ ELNKR 586_ LHTKG 591_ STEER 596_ HLLYG 601_ RPAVL 606_ YRTRY 611_ DILYH 616_ TDFES 621_ GYSEI 626_ FLMPL 631_ WTSYT 636_ VSKQA 641_ EVSSV 646_ PDHLT 651_ SCVRP 656_ DVRVS 661_ PSFSQ 666_ NCLAY 671_ KNDKQ 676_ MSYGF 681_ LFPPY 686_ LSSSP 691_ EAKYD 696_ AFLVT 701_ NMVPM 706_ YPAFK 711_ RVWNY 716_ FQRVL 721_ VKKYA 726_ SERNG 731_ VNVIS 736_ GPIFD 741_ YDYDG 746_ LHDTE 751_ DKIKQ 756_ YVEGS 761_ SIPVP 766_ THYYS 771_ IITSC 776_ LDFTQ 781_ PADKC 786_ DGPLS 791_ VSSFI 796_ LPHRP 801_ DNEES 806_ CNSSE 811_ DESKW 816_ VEELM 821_ KMHTA 826_ RVRDI 831_ EHLTS 836_ LDFFR 841_ KTSRS 846_ YPEIL 851_ TLKTY 856_LHTYE
1: Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:14500380, PubMed:15769751, PubMed:26371182, PubMed:27754931). Its major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:14500380, PubMed:27754931). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:12176993, PubMed:15769751). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252)