BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)
1_MSGDT 6_ CLCPA 11_ SGAKP 16_ KLSGF 21_ KGGGL 26_ GNKYV 31_ QLNVG 36_ GSLYY 41_ TTVRA 46_ LTRHD 51_ TMLKA 56_ MFSGR 61_ MEVLT 66_ DKEGW 71_ ILIDR 76_ CGKHF 81_ GTILN 86_ YLRDD 91_ TITLP 96_ QNRQE 101_ IKELM 106_ AEAKY 111_ YLIQG 116_ LVNMC 121_ QSALQ 126_ DKKDS 131_ YQPVC 136_ NIPII 141_ TSLKE 146_ EERLI 151_ ESSTK 156_ PVVKL 161_ LYNRS 166_ NNKYS 171_ YTSNS 176_ DDHLL 181_ KNIEL 186_ FDKLS 191_ LRFNG 196_ RVLFI 201_ KDVIG 206_ DEICC 211_ WSFYG 216_ QGRKL 221_ AEVCC 226_ TSIVY 231_ ATEKK 236_ QTKVE 241_ FPEAR 246_ IYEET 251_ LNVLL 256_ YETPR 261_ VPDNS 266_ LLEAT 271_ SRSRS 276_ QASPS 281_ EDEET 286_ FELRD 291_ RVRRI 296_ HVKRY 301_ STYDD 306_ RQLGH 311_QSTHR
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity