Plakophilin-1 (Band 6 protein) (B6P)
1_MNHSP 6_ LKTAL 11_ AYECF 16_ QDQDN 21_ STLAL 26_ PSDQK 31_ MKTGT 36_ SGRQR 41_ VQEQV 46_ MMTVK 51_ RQKSK 56_ SSQSS 61_ TLSHS 66_ NRGSM 71_ YDGLA 76_ DNYNY 81_ GTTSR 86_ SSYYS 91_ KFQAG 96_ NGSWG 101_ YPIYN 106_ GTLKR 111_ EPDNR 116_ RFSSY 121_ SQMEN 126_ WSRHY 131_ PRGSC 136_ NTTGA 141_ GSDIC 146_ FMQKI 151_ KASRS 156_ EPDLY 161_ CDPRG 166_ TLRKG 171_ TLGSK 176_ GQKTT 181_ QNRYS 186_ FYSTC 191_ SGQKA 196_ IKKCP 201_ VRPPS 206_ CASKQ 211_ DPVYI 216_ PPISC 221_ NKDLS 226_ FGHSR 231_ ASSKI 236_ CSEDI 241_ ECSGL 246_ TIPKA 251_ VQYLS 256_ SQDEK 261_ YQAIG 266_ AYYIQ 271_ HTCFQ 276_ DESAK 281_ QQVYQ 286_ LGGIC 291_ KLVDL 296_ LRSPN 301_ QNVQQ 306_ AAAGA 311_ LRNLV 316_ FRSTT 321_ NKLET 326_ RRQNG 331_ IREAV 336_ SLLRR 341_ TGNAE 346_ IQKQL 351_ TGLLW 356_ NLSST 361_ DELKE 366_ ELIAD 371_ ALPVL 376_ ADRVI 381_ IPFSG 386_ WCDGN 391_ SNMSR 396_ EVVDP 401_ EVFFN 406_ ATGCL 411_ RKRLG 416_ MRELL 421_ ALVPQ 426_ RATSS 431_ RVNLS 436_ SADAG 441_ RQTMR 446_ NYSGL 451_ IDSLM 456_ AYVQN 461_ CVAAS 466_ RCDDK 471_ SVENC 476_ MCVLH 481_ NLSYR 486_ LDAEV 491_ PTRYR 496_ QLEYN 501_ ARNAY 506_ TEKSS 511_ TGCFS 516_ NKSDK 521_ MMNNN 526_ YDCPL 531_ PEEET 536_ NPKGS 541_ GWLYH 546_ SDAIR 551_ TYLNL 556_ MGKSK 561_ KDATL 566_ EACAG 571_ ALQNL 576_ TASKG 581_ LMSSG 586_ MSQLI 591_ GLKEK 596_ GLPQI 601_ ARLLQ 606_ SGNSD 611_ VVRSG 616_ ASLLS 621_ NMSRH 626_ PLLHR 631_ VMGNQ 636_ VFPEV 641_ TRLLT 646_ SHTGN 651_ TSNSE 656_ DILSS 661_ ACYTV 666_ RNLMA 671_ SQPQL 676_ AKQYF 681_ SSSML 686_ NNIIN 691_ LCRSS 696_ ASPKA 701_ AEAAR 706_ LLLSD 711_ MWSSK 716_ ELQGV 721_ LRQQG 726_ FDRNM 731_ LGTLA 736_ GANSL 741_RNFTS
1: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333)