Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)
1_MSSSG 6_ LNSEK 11_ VAALI 16_ QKLNS 21_ DPQFV 26_ LAQNV 31_ GTTHD 36_ LLDIC 41_ LKRAT 46_ VQRAQ 51_ HVFQH 56_ AVPQE 61_ GKPIT 66_ NQKSS 71_ GRCWI 76_ FSCLN 81_ VMRLP 86_ FMKKL 91_ NIEEF 96_ EFSQS 101_ YLFFW 106_ DKVER 111_ CYFFL 116_ SAFVD 121_ TAQRK 126_ EPEDG 131_ RLVQF 136_ LLMNP 141_ ANDGG 146_ QWDML 151_ VNIVE 156_ KYGVI 161_ PKKCF 166_ PESYT 171_ TEATR 176_ RMNDI 181_ LNHKM 186_ REFCI 191_ RLRNL 196_ VHSGA 201_ TKGEI 206_ SATQD 211_ VMMEE 216_ IFRVV 221_ CICLG 226_ NPPET 231_ FTWEY 236_ RDKDK 241_ NYQKI 246_ GPITP 251_ LEFYR 256_ EHVKP 261_ LFNME 266_ DKICL 271_ VNDPR 276_ PQHKY 281_ NKLYT 286_ VEYLS 291_ NMVGG 296_ RKTLY 301_ NNQPI 306_ DFLKK 311_ MVAAS 316_ IKDGE 321_ AVWFG 326_ CDVGK 331_ HFNSK 336_ LGLSD 341_ MNLYD 346_ HELVF 351_ GVSLK 356_ NMNKA 361_ ERLTF 366_ GESLM 371_ THAMT 376_ FTAVS 381_ EKDDQ 386_ DGAFT 391_ KWRVE 396_ NSWGE 401_ DHGHK 406_ GYLCM 411_ TDEWF 416_ SEYVY 421_ EVVVD 426_ RKHVP 431_ EEVLA 436_ VLEQE 441_ PIILP 446_AWDPM
1: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity