Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
1_MTSSL 6_ QRPWR 11_ VPWLP 16_ WTILL 21_ VSTAA 26_ ASQNQ 31_ ERLCA 36_ FKDPY 41_ QQDLG 46_ IGESR 51_ ISHEN 56_ GTILC 61_ SKGST 66_ CYGLW 71_ EKSKG 76_ DINLV 81_ KQGCW 86_ SHIGD 91_ PQECH 96_ YEECV 101_ VTTTP 106_ PSIQN 111_ GTYRF 116_ CCCST 121_ DLCNV 126_ NFTEN 131_ FPPPD 136_ TTPLS 141_ PPHSF 146_ NRDET 151_ IIIAL 156_ ASVSV 161_ LAVLI 166_ VALCF 171_ GYRML 176_ TGDRK 181_ QGLHS 186_ MNMME 191_ AAASE 196_ PSLDL 201_ DNLKL 206_ LELIG 211_ RGRYG 216_ AVYKG 221_ SLDER 226_ PVAVK 231_ VFSFA 236_ NRQNF 241_ INEKN 246_ IYRVP 251_ LMEHD 256_ NIARF 261_ IVGDE 266_ RVTAD 271_ GRMEY 276_ LLVME 281_ YYPNG 286_ SLCKY 291_ LSLHT 296_ SDWVS 301_ SCRLA 306_ HSVTR 311_ GLAYL 316_ HTELP 321_ RGDHY 326_ KPAIS 331_ HRDLN 336_ SRNVL 341_ VKNDG 346_ TCVIS 351_ DFGLS 356_ MRLTG 361_ NRLVR 366_ PGEED 371_ NAAIS 376_ EVGTI 381_ RYMAP 386_ EVLEG 391_ AVNLR 396_ DCESA 401_ LKQVD 406_ MYALG 411_ LIYWE 416_ IFMRC 421_ TDLFP 426_ GESVP 431_ EYQMA 436_ FQTEV 441_ GNHPT 446_ FEDMQ 451_ VLVSR 456_ EKQRP 461_ KFPEA 466_ WKENS 471_ LAVRS 476_ LKETI 481_ EDCWD 486_ QDAEA 491_ RLTAQ 496_ CAEER 501_ MAELM 506_ MIWER 511_ NKSVS 516_ PTVNP 521_ MSTAM 526_ QNERN 531_ LSHNR 536_ RVPKI 541_ GPYPD 546_ YSSSS 551_ YIEDS 556_ IHHTD 561_ SIVKN 566_ ISSEH 571_ SMSST 576_ PLTIG 581_ EKNRN 586_ SINYE 591_ RQQAQ 596_ ARIPS 601_ PETSV 606_ TSLST 611_ NTTTT 616_ NTTGL 621_ TPSTG 626_ MTTIS 631_ EMPYP 636_ DETNL 641_ HTTNV 646_ AQSIG 651_ PTPVC 656_ LQLTE 661_ EDLET 666_ NKLDP 671_ KEVDK 676_ NLKES 681_ SDENL 686_ MEHSL 691_ KQFSG 696_ PDPLS 701_ STSSS 706_ LLYPL 711_ IKLAV 716_ EATGQ 721_ QDFTQ 726_ TANGQ 731_ ACLIP 736_ DVLPT 741_ QIYPL 746_ PKQQN 751_ LPKRP 756_ TSLPL 761_ NTKNS 766_ TKEPR 771_ LKFGS 776_ KHKSN 781_ LKQVE 786_ TGVAK 791_ MNTIN 796_ AAEPH 801_ VVTVT 806_ MNGVA 811_ GRNHS 816_ VNSHA 821_ ATTQY 826_ ANGTV 831_ LSGQT 836_ TNIVT 841_ HRAQE 846_ MLQNQ 851_ FIGED 856_ TRLNI 861_ NSSPD 866_ EHEPL 871_ LRREQ 876_ QAGHD 881_ EGVLD 886_ RLVDR 891_ RERPL 896_ EGGRT 901_ NSNNN 906_ NSNPC 911_ SEQDV 916_ LAQGV 921_ PSTAA 926_ DPGPS 931_ KPRRA 936_ QRPNS 941_ LDLSA 946_ TNVLD 951_ GSSIQ 956_ IGEST 961_ QDGKS 966_ GSGEK 971_ IKKRV 976_ KTPYS 981_ LKRWR 986_ PSTWV 991_ ISTES 996_ LDCEV 1001_ NNNGS 1006_ NRAVH 1011_ SKSST 1016_ AVYLA 1021_ EGGTA 1026_ TTMVS 1031_KDIGM
1: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044)