General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)
1_MDEEP 6_ ERTKR 11_ WEGGY 16_ ERTWE 21_ ILKED 26_ ESGSL 31_ KATIE 36_ DILFK 41_ AKRKR 46_ VFEHH 51_ GQVRL 56_ GMMRH 61_ LYVVV 66_ DGSRT 71_ MEDQD 76_ LKPNR 81_ LTCTL 86_ KLLEY 91_ FVEEY 96_ FDQNP 101_ ISQIG 106_ IIVTK 111_ SKRAE 116_ KLTEL 121_ SGNPR 126_ KHITS 131_ LKKAV 136_ DMTCH 141_ GEPSL 146_ YNSLS 151_ IAMQT 156_ LKHMP 161_ GHTSR 166_ EVLII 171_ FSSLT 176_ TCDPS 181_ NIYDL 186_ IKTLK 191_ AAKIR 196_ VSVIG 201_ LSAEV 206_ RVCTV 211_ LARET 216_ GGTYH 221_ VILDE 226_ SHYKE 231_ LLTHH 236_ VSPPP 241_ ASSSS 246_ ECSLI 251_ RMGFP 256_ QHTIA 261_ SLSDQ 266_ DAKPS 271_ FSMAH 276_ LDGNT 281_ EPGLT 286_ LGGYF 291_ CPQCR 296_ AKYCE 301_ LPVEC 306_ KICGL 311_ TLVSA 316_ PHLAR 321_ SYHHL 326_ FPLDA 331_ FQEIP 336_ LEEYN 341_ GERFC 346_ YGCQG 351_ ELKDQ 356_ HVYVC 361_ AVCQN 366_ VFCVD 371_ CDVFV 376_ HDSLH 381_ CCPGC 386_IHKIP
1: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter