General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit)
1_MVSDE 6_ DELNL 11_ LVIVV 16_ DANPI 21_ WWGKQ 26_ ALKES 31_ QFTLS 36_ KCIDA 41_ VMVLG 46_ NSHLF 51_ MNRSN 56_ KLAVI 61_ ASHIQ 66_ ESRFL 71_ YPGKN 76_ GRLGD 81_ FFGDP 86_ GNPPE 91_ FNPSG 96_ SKDGK 101_ YELLT 106_ SANEV 111_ IVEEI 116_ KDLMT 121_ KSDIK 126_ GQHTE 131_ TLLAG 136_ SLAKA 141_ LCYIH 146_ RMNKE 151_ VKDNQ 156_ EMKSR 161_ ILVIK 166_ AAEDS 171_ ALQYM 176_ NFMNV 181_ IFAAQ 186_ KQNIL 191_ IDACV 196_ LDSDS 201_ GLLQQ 206_ ACDIT 211_ GGLYL 216_ KVPQM 221_ PSLLQ 226_ YLLWV 231_ FLPDQ 236_ DQRSQ 241_ LILPP 246_ PVHVD 251_ YRAAC 256_ FCHRN 261_ LIEIG 266_ YVCSV 271_ CLSIF 276_ CNFSP 281_ ICTTC 286_ ETAFK 291_ ISLPP 296_ VLKAK 301_KKKLK
1: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription