Nuclear nucleic acid-binding protein C1D (hC1D)
1_MAGEE 6_ INEDY 11_ PVEIH 16_ EYLSA 21_ FENSI 26_ GAVDE 31_ MLKTM 36_ MSVSR 41_ NELLQ 46_ KLDPL 51_ EQAKV 56_ DLVSA 61_ YTLNS 66_ MFWVY 71_ LATQG 76_ VNPKE 81_ HPVKQ 86_ ELERI 91_ RVYMN 96_ RVKEI 101_ TDKKK 106_ AGKLD 111_ RGAAS 116_ RFVKN 121_ ALWEP 126_ KSKNA 131_ SKVAN 136_KGKSK
1: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity)