Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
1_MDTDS 6_ QRSHL 11_ SSFTM 16_ KLMDK 21_ FHSPK 26_ IKRTP 31_ SKKGK 36_ PAEVS 41_ VKIPE 46_ KPVNK 51_ EATDR 56_ FLPEG 61_ YPLPL 66_ DLEQQ 71_ AVEFM 76_ STSAV 81_ ASRSQ 86_ RQKNL 91_ SWLEE 96_ KEKEV 101_ VSALR 106_ YFKTI 111_ VDKMA 116_ IDKKV 121_ LEMLP 126_ GSASK 131_ VLEAI 136_ LPLVQ 141_ NDPRI 146_ QHSSA 151_ LSSCY 156_ SRVYQ 161_ SLANL 166_ IRWSD 171_ QVMLE 176_ GVNSE 181_ DKEMV 186_ TTVKG 191_ VIKAV 196_ LDGVK 201_ ELVRL 206_ TIEKQ 211_ GRPSP 216_ TSPVK 221_ PSSPA 226_ SKPDG 231_ PAELP 236_ LTDRE 241_ VEILN 246_ KTTGM 251_ SQSTE 256_ LLPDA 261_ TDEEV 266_ APPKP 271_ PLPGI 276_ RVVDN 281_ SPPPA 286_ LPPKK 291_ RQSAP 296_ SPTRV 301_ AVVAP 306_ MSRAT 311_ SGSSL 316_ PVGIN 321_ RQDFD 326_ VDCYA 331_ QRRLS 336_ GGSHS 341_ YGGES 346_ PRLSP 351_ CSSIG 356_ KLSKS 361_ DEQLS 366_ SLDRD 371_ SGQCS 376_ RNTSC 381_ ETLDH 386_ YDPDY 391_ EFLQQ 396_ DLSNA 401_ DQIPQ 406_ QTAWN 411_ LSPLP 416_ ESLGE 421_ SGSPF 426_ LGPPF 431_ QLPLG 436_ GHPQP 441_ DGPLA 446_ PGQQT 451_ DTPPA 456_ LPEKK 461_ RRSAA 466_ SQTAD 471_ GSGCR 476_ VSYER 481_ HPSQY 486_ DNISG 491_ EDLQS 496_ TAPIP 501_ SVPYA 506_ PFAAI 511_ LPFQH 516_ GGSSA 521_ PVEFV 526_ GDFTA 531_ PESTG 536_ DPEKP 541_ PPLPE 546_ KKNKH 551_ MLAYM 556_ QLLED 561_ YSEPQ 566_ PSMFY 571_ QTPQN 576_ EHIYQ 581_ QKNKL 586_ LMEVY 591_ GFSDS 596_ FSGVD 601_ SVQEL 606_ APPPA 611_ LPPKQ 616_ RQLEP 621_ PAGKD 626_ GHPRD 631_ PSAVS 636_ GVPGK 641_ DSRDG 646_ SERAP 651_ KSPDA 656_ LESAQ 661_ SEEEV 666_ DELSL 671_ IDHNE 676_ IMSRL 681_ TLKQE 686_ GDDGP 691_ DVRGG 696_ SGDIL 701_ LVHAT 706_ ETDRK 711_ DLVLY 716_ CEAFL 721_ TTYRT 726_ FISPE 731_ ELIKK 736_ LQYRY 741_ EKFSP 746_ FADTF 751_ KKRVS 756_ KNTFF 761_ VLVRV 766_ VDELC 771_ LVELT 776_ EEILK 781_ LLMEL 786_ VFRLV 791_ CNGEL 796_ SLARV 801_ LRKNI 806_ LDKVD 811_ QKKLL 816_ RCATS 821_ SQPLA 826_ ARGVA 831_ ARPGT 836_ LHDFH 841_ SHEIA 846_ EQLTL 851_ LDAEL 856_ FYKIE 861_ IPEVL 866_ LWAKE 871_ QNEEK 876_ SPNLT 881_ QFTEH 886_ FNNMS 891_ YWVRS 896_ IIMLQ 901_ EKAQD 906_ RERLL 911_ LKFIK 916_ IMKHL 921_ RKLNN 926_ FNSYL 931_ AILSA 936_ LDSAP 941_ IRRLE 946_ WQKQT 951_ SEGLA 956_ EYCTL 961_ IDSSS 966_ SFRAY 971_ RAALS 976_ EVEPP 981_ CIPYL 986_ GLILQ 991_ DLTFV 996_ HLGNP 1001_ DYIDG 1006_ KVNFS 1011_ KRWQQ 1016_ FNILD 1021_ SMRCF 1026_ QQAHY 1031_ DMRRN 1036_ DDIIN 1041_ FFNDF 1046_ SDHLA 1051_ EEALW 1056_ ELSLK 1061_ IKPRN 1066_ ITRRK 1071_TDREE
1: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth