Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
1_MVNEN 6_ TRMYI 11_ PEENH 16_ QGSNY 21_ GSPRP 26_ AHANM 31_ NANAA 36_ AGLAP 41_ EHIPT 46_ PGAAL 51_ SWQAA 56_ IDAAR 61_ QAKLM 66_ GSAGN 71_ ATIST 76_ VSSTQ 81_ RKRQQ 86_ YGKPK 91_ KQGST 96_ TATRP 101_ PRALL 106_ CLTLK 111_ NPIRR 116_ ACISI 121_ VEWKP 126_ FEIII 131_ LLTIF 136_ ANCVA 141_ LAIYI 146_ PFPED 151_ DSNAT 156_ NSNLE 161_ RVEYL 166_ FLIIF 171_ TVEAF 176_ LKVIA 181_ YGLLF 186_ HPNAY 191_ LRNGW 196_ NLLDF 201_ IIVVV 206_ GLFSA 211_ ILEQA 216_ TKADG 221_ ANALG 226_ GKGAG 231_ FDVKA 236_ LRAFR 241_ VLRPL 246_ RLVSG 251_ VPSLQ 256_ VVLNS 261_ IIKAM 266_ VPLLH 271_ IALLV 276_ LFVII 281_ IYAII 286_ GLELF 291_ MGKMH 296_ KTCYN 301_ QEGIA 306_ DVPAE 311_ DDPSP 316_ CALET 321_ GHGRQ 326_ CQNGT 331_ VCKPG 336_ WDGPK 341_ HGITN 346_ FDNFA 351_ FAMLT 356_ VFQCI 361_ TMEGW 366_ TDVLY 371_ WVNDA 376_ VGRDW 381_ PWIYF 386_ VTLII 391_ IGSFF 396_ VLNLV 401_ LGVLS 406_ GEFSK 411_ EREKA 416_ KARGD 421_ FQKLR 426_ EKQQL 431_ EEDLK 436_ GYLDW 441_ ITQAE 446_ DIDPE 451_ NEDEG 456_ MDEEK 461_ PRNMS 466_ MPTSE 471_ TESVN 476_ TENVA 481_ GGDIE 486_ GENCG 491_ ARLAH 496_ RISKS 501_ KFSRY 506_ WRRWN 511_ RFCRR 516_ KCRAA 521_ VKSNV 526_ FYWLV 531_ IFLVF 536_ LNTLT 541_ IASEH 546_ YNQPN 551_ WLTEV 556_ QDTAN 561_ KALLA 566_ LFTAE 571_ MLLKM 576_ YSLGL 581_ QAYFV 586_ SLFNR 591_ FDCFV 596_ VCGGI 601_ LETIL 606_ VETKI 611_ MSPLG 616_ ISVLR 621_ CVRLL 626_ RIFKI 631_ TRYWN 636_ SLSNL 641_ VASLL 646_ NSVRS 651_ IASLL 656_ LLLFL 661_ FIIIF 666_ SLLGM 671_ QLFGG 676_ KFNFD 681_ EMQTR 686_ RSTFD 691_ NFPQS 696_ LLTVF 701_ QILTG 706_ EDWNS 711_ VMYDG 716_ IMAYG 721_ GPSFP 726_ GMLVC 731_ IYFII 736_ LFICG 741_ NYILL 746_ NVFLA 751_ IAVDN 756_ LADAE 761_ SLTSA 766_ QKEEE 771_ EEKER 776_ KKLAR 781_ TASPE 786_ KKQEL 791_ VEKPA 796_ VGESK 801_ EEKIE 806_ LKSIT 811_ ADGES 816_ PPATK 821_ INMDD 826_ LQPNE 831_ NEDKS 836_ PYPNP 841_ ETTGE 846_ EDEEE 851_ PEMPV 856_ GPRPR 861_ PLSEL 866_ HLKEK 871_ AVPMP 876_ EASAF 881_ FIFSS 886_ NNRFR 891_ LQCHR 896_ IVNDT 901_ IFTNL 906_ ILFFI 911_ LLSSI 916_ SLAAE 921_ DPVQH 926_ TSFRN 931_ HILFY 936_ FDIVF 941_ TTIFT 946_ IEIAL 951_ KILGN 956_ ADYVF 961_ TSIFT 966_ LEIIL 971_ KMTAY 976_ GAFLH 981_ KGSFC 986_ RNYFN 991_ ILDLL 996_ VVSVS 1001_ LISFG 1006_ IQSSA 1011_ INVVK 1016_ ILRVL 1021_ RVLRP 1026_ LRAIN 1031_ RAKGL 1036_ KHVVQ 1041_ CVFVA 1046_ IRTIG 1051_ NIVIV 1056_ TTLLQ 1061_ FMFAC 1066_ IGVQL 1071_ FKGKL 1076_ YTCSD 1081_ SSKQT 1086_ EAECK 1091_ GNYIT 1096_ YKDGE 1101_ VDHPI 1106_ IQPRS 1111_ WENSK 1116_ FDFDN 1121_ VLAAM 1126_ MALFT 1131_ VSTFE 1136_ GWPEL 1141_ LYRSI 1146_ DSHTE 1151_ DKGPI 1156_ YNYRV 1161_ EISIF 1166_ FIIYI 1171_ IIIAF 1176_ FMMNI 1181_ FVGFV 1186_ IVTFQ 1191_ EQGEQ 1196_ EYKNC 1201_ ELDKN 1206_ QRQCV 1211_ EYALK 1216_ ARPLR 1221_ RYIPK 1226_ NQHQY 1231_ KVWYV 1236_ VNSTY 1241_ FEYLM 1246_ FVLIL 1251_ LNTIC 1256_ LAMQH 1261_ YGQSC 1266_ LFKIA 1271_ MNILN 1276_ MLFTG 1281_ LFTVE 1286_ MILKL 1291_ IAFKP 1296_ KGYFS 1301_ DPWNV 1306_ FDFLI 1311_ VIGSI 1316_ IDVIL 1321_ SETNH 1326_ YFCDA 1331_ WNTFD 1336_ ALIVV 1341_ GSIVD 1346_ IAITE 1351_ VNPAE 1356_ HTQCS 1361_ PSMNA 1366_ EENSR 1371_ ISITF 1376_ FRLFR 1381_ VMRLV 1386_ KLLSR 1391_ GEGIR 1396_ TLLWT 1401_ FIKSF 1406_ QALPY 1411_ VALLI 1416_ VMLFF 1421_ IYAVI 1426_ GMQVF 1431_ GKIAL 1436_ NDTTE 1441_ INRNN 1446_ NFQTF 1451_ PQAVL 1456_ LLFRC 1461_ ATGEA 1466_ WQDIM 1471_ LACMP 1476_ GKKCA 1481_ PESEP 1486_ SNSTE 1491_ GETPC 1496_ GSSFA 1501_ VFYFI 1506_ SFYML 1511_ CAFLI 1516_ INLFV 1521_ AVIMD 1526_ NFDYL 1531_ TRDWS 1536_ ILGPH 1541_ HLDEF 1546_ KRIWA 1551_ EYDPE 1556_ AKGRI 1561_ KHLDV 1566_ VTLLR 1571_ RIQPP 1576_ LGFGK 1581_ LCPHR 1586_ VACKR 1591_ LVSMN 1596_ MPLNS 1601_ DGTVM 1606_ FNATL 1611_ FALVR 1616_ TALRI 1621_ KTEGN 1626_ LEQAN 1631_ EELRA 1636_ IIKKI 1641_ WKRTS 1646_ MKLLD 1651_ QVVPP 1656_ AGDDE 1661_ VTVGK 1666_ FYATF 1671_ LIQEY 1676_ FRKFK 1681_ KRKEQ 1686_ GLVGK 1691_ PSQRN 1696_ ALSLQ 1701_ AGLRT 1706_ LHDIG 1711_ PEIRR 1716_ AISGD 1721_ LTAEE 1726_ ELDKA 1731_ MKEAV 1736_ SAASE 1741_ DDIFR 1746_ RAGGL 1751_ FGNHV 1756_ SYYQS 1761_ DGRSA 1766_ FPQTF 1771_ TTQRP 1776_ LHINK 1781_ AGSSQ 1786_ GDTES 1791_ PSHEK 1796_ LVDST 1801_ FTPSS 1806_ YSSTG 1811_ SNANI 1816_ NNANN 1821_ TALGR 1826_ LPRPA 1831_ GYPST 1836_ VSTVE 1841_ GHGPP 1846_ LSPAI 1851_ RVQEV 1856_ AWKLS 1861_ SNRER 1866_ HVPMC 1871_ EDLEL 1876_ RRDSG 1881_ SAGTQ 1886_ AHCLL 1891_ LRKAN 1896_ PSRCH 1901_ SRESQ 1906_ AAMAG 1911_ QEETS 1916_ QDETY 1921_ EVKMN 1926_ HDTEA 1931_ CSEPS 1936_ LLSTE 1941_ MLSYQ 1946_ DDENR 1951_ QLTLP 1956_ EEDKR 1961_ DIRQS 1966_ PKRGF 1971_ LRSAS 1976_ LGRRA 1981_ SFHLE 1986_ CLKRQ 1991_ KDRGG 1996_ DISQK 2001_ TVLPL 2006_ HLVHH 2011_ QALAV 2016_ AGLSP 2021_ LLQRS 2026_ HSPAS 2031_ FPRPF 2036_ ATPPA 2041_ TPGSR 2046_ GWPPQ 2051_ PVPTL 2056_ RLEGV 2061_ ESSEK 2066_ LNSSF 2071_ PSIHC 2076_ GSWAE 2081_ TTPGG 2086_ GGSSA 2091_ ARRVR 2096_ PVSLM 2101_ VPSQA 2106_ GAPGR 2111_ QFHGS 2116_ ASSLV 2121_ EAVLI 2126_ SEGLG 2131_ QFAQD 2136_ PKFIE 2141_ VTTQE 2146_ LADAC 2151_ DMTIE 2156_ EMESA 2161_ ADNIL 2166_ SGGAP 2171_ QSPNG 2176_ ALLPF 2181_ VNCRD 2186_ AGQDR 2191_ AGGEE 2196_ DAGCV 2201_ RARGR 2206_ PSEEE 2211_ LQDSR 2216_VYVSS
1: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable)
2: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
3: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
4: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
5: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
6: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
7: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
8: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
9: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
10: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
11: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
12: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
13: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
14: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
15: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
16: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
17: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
18: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
19: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930)