Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
1_MASNS 6_ LFSTV 11_ TPCQQ 16_ NFFWD 21_ PSTSR 26_ RFSPP 31_ SSSLQ 36_ PGKMS 41_ DVSPV 46_ VAAQQ 51_ QQQQQ 56_ QQQQQ 61_ QQQQQ 66_ QQQQQ 71_ QEAAA 76_ AAAAA 81_ AAAAA 86_ AAAAV 91_ PRLRP 96_ PHDNR 101_ TMVEI 106_ IADHP 111_ AELVR 116_ TDSPN 121_ FLCSV 126_ LPSHW 131_ RCNKT 136_ LPVAF 141_ KVVAL 146_ GEVPD 151_ GTVVT 156_ VMAGN 161_ DENYS 166_ AELRN 171_ ASAVM 176_ KNQVA 181_ RFNDL 186_ RFVGR 191_ SGRGK 196_ SFTLT 201_ ITVFT 206_ NPPQV 211_ ATYHR 216_ AIKVT 221_ VDGPR 226_ EPRRH 231_ RQKLD 236_ DSKPS 241_ LFSDR 246_ LSDLG 251_ RIPHP 256_ SMRVG 261_ VPPQN 266_ PRPSL 271_ NSAPS 276_ PFNPQ 281_ GQSQI 286_ TDPRQ 291_ AQSSP 296_ PWSYD 301_ QSYPS 306_ YLSQM 311_ TSPSI 316_ HSTTP 321_ LSSTR 326_ GTGLP 331_ AITDV 336_ PRRIS 341_ DDDTA 346_ TSDFC 351_ LWPST 356_ LSKKS 361_ QAGAS 366_ ELGPF 371_ SDPRQ 376_ FPSIS 381_ SLTES 386_ RFSNP 391_ RMHYP 396_ ATFTY 401_ TPPVT 406_ SGMSL 411_ GMSAT 416_ THYHT 421_ YLPPP 426_ YPGSS 431_ QSQSG 436_ PFQTS 441_ STPYL 446_ YYGTS 451_ SGSYQ 456_ FPMVP 461_ GGDRS 466_ PSRML 471_ PPCTT 476_ TSNGS 481_ TLLNP 486_ NLPNQ 491_ NDGVD 496_ ADGSH 501_ SSSPT 506_ VLNSS 511_ GRMDE 516_SVWRP
1: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation