Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
1_MPRVV 6_ PDQRS 11_ KFENE 16_ EFFRK 21_ LSREC 26_ EIKYT 31_ GFRDR 36_ PHEER 41_ QARFQ 46_ NACRD 51_ GRSEI 56_ AFVAT 61_ GTNLS 66_ LQFFP 71_ ASWQG 76_ EQRQT 81_ PSREY 86_ VDLER 91_ EAGKV 96_ YLKAP 101_ MILNG 106_ VCVIW 111_ KGWID 116_ LQRLD 121_ GMGCL 126_ EFDEE 131_ RAQQE 136_ DALAQ 141_ QAFEE 146_ ARRRT 151_ REFED 156_ RDRSH 161_ REEME 166_ VRVSQ 171_ LLAVT 176_GKKTT
1: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation
2: (Microbial infection) Following infection, hijacked by the HIV-1 Vif protein, leading to the formation a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) that catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:22190037, PubMed:31792451, PubMed:36598981, PubMed:36754086, PubMed:37419875). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699). Association with HIV-1 Vif protein also inhibits the transcription coactivator activity of CBFB/CBF-beta (PubMed:22190037)