Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)
1_MLSSV 6_ CVSSF 11_ RGRQG 16_ ASKQQ 21_ PAPPP 26_ QPPES 31_ PPPPP 36_ LPPQQ 41_ QQPAQ 46_ PGPAA 51_ SPAGP 56_ PAPRG 61_ PGDRR 66_ AEPCP 71_ GLPAA 76_ AMGRH 81_ GGGGG 86_ DSGKI 91_ VINVG 96_ GVRHE 101_ TYRST 106_ LRTLP 111_ GTRLA 116_ GLTEP 121_ EAAAR 126_ FDYDP 131_ GADEF 136_ FFDRH 141_ PGVFA 146_ YVLNY 151_ YRTGK 156_ LHCPA 161_ DVCGP 166_ LFEEE 171_ LGFWG 176_ IDETD 181_ VEACC 186_ WMTYR 191_ QHRDA 196_ EEALD 201_ SFEAP 206_ DPAGA 211_ ANAAN 216_ AAGAH 221_ DGGLD 226_ DEAGA 231_ GGGGL 236_ DGAGG 241_ ELKRL 246_ CFQDA 251_ GGGAG 256_ GPPGG 261_ AGGAG 266_ GTWWR 271_ RWQPR 276_ VWALF 281_ EDPYS 286_ SRAAR 291_ YVAFA 296_ SLFFI 301_ LISIT 306_ TFCLE 311_ THEGF 316_ IHISN 321_ KTVTQ 326_ ASPIP 331_ GAPPE 336_ NITNV 341_ EVETE 346_ PFLTY 351_ VEGVC 356_ VVWFT 361_ FEFLM 366_ RITFC 371_ PDKVE 376_ FLKSS 381_ LNIID 386_ CVAIL 391_ PFYLE 396_ VGLSG 401_ LSSKA 406_ AKDVL 411_ GFLRV 416_ VRFVR 421_ ILRIF 426_ KLTRH 431_ FVGLR 436_ VLGHT 441_ LRAST 446_ NEFLL 451_ LIIFL 456_ ALGVL 461_ IFATM 466_ IYYAE 471_ RIGAD 476_ PDDIL 481_ GSNHT 486_ YFKNI 491_ PIGFW 496_ WAVVT 501_ MTTLG 506_ YGDMY 511_ PKTWS 516_ GMLVG 521_ ALCAL 526_ AGVLT 531_ IAMPV 536_ PVIVN 541_ NFGMY 546_ YSLAM 551_ AKQKL 556_ PKKKN 561_ KHIPR 566_ PPQPG 571_ SPNYC 576_ KPDPP 581_ PPPPP 586_ HPHHG 591_ SGGIS 596_ PPPPI 601_ TPPSM 606_ GVTVA 611_ GAYPA 616_ GPHTH 621_ PGLLR 626_ GGAGG 631_ LGIMG 636_ LPPLP 641_ APGEP 646_ CPLAQ 651_ EEVIE 656_ INRAD 661_ PRPNG 666_ DPAAA 671_ ALAHE 676_ DCPAI 681_ DQPAM 686_ SPEDK 691_ SPITP 696_ GSRGR 701_ YSRDR 706_ ACFLL 711_ TDYAP 716_ SPDGS 721_ IRKAT 726_ GAPPL 731_ PPQDW 736_ RKPGP 741_ PSFLP 746_ DLNAN 751_AAAWI
1: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:22289912, PubMed:23734863, PubMed:25756792, PubMed:26997484). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:23734863, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484)