Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]
1_MESHS 6_ RAGKS 11_ RKSAK 16_ FRSIS 21_ RSLML 26_ CNAKT 31_ SDDGS 36_ SPDEK 41_ YPDPF 46_ EISLA 51_ QGKEG 56_ IFHSS 61_ VQLAD 66_ TSEAG 71_ PSSVP 76_ DLALA 81_ SEAAQ 86_ LQAAG 91_ NDRGK 96_ TCRRI 101_ FFMKE 106_ SSTAS 111_ SREKP 116_ GKLEA 121_ QSSNF 126_ LFPKA 131_ CHQRA 136_ RSNST 141_ SVNPY 146_ CTREI 151_ DFPMT 156_ KKSAA 161_ PTDRQ 166_ PYSLC 171_ SNRKS 176_ LSQQL 181_ DCPAG 186_ KAAGT 191_ SRPTR 196_ SLSTA 201_ QLVQP 206_ SGGLQ 211_ ASVIS 216_ NIVLM 221_ KGQAK 226_ GLGFS 231_ IVGGK 236_ DSIYG 241_ PIGIY 246_ VKTIF 251_ AGGAA 256_ AADGR 261_ LQEGD 266_ EILEL 271_ NGESM 276_ AGLTH 281_ QDALQ 286_ KFKQA 291_ KKGLL 296_ TLTVR 301_ TRLTA 306_ PPSLC 311_ SHLSP 316_ PLCRS 321_ LSSST 326_ CITKD 331_ SSSFA 336_ LESPS 341_ APIST 346_ AKPNY 351_ RIMVE 356_ VSLQK 361_ EAGVG 366_ LGIGL 371_ CSVPY 376_ FQCIS 381_ GIFVH 386_ TLSPG 391_ SVAHL 396_ DGRLR 401_ CGDEI 406_ VEISD 411_ SPVHC 416_ LTLNE 421_ VYTIL 426_ SHCDP 431_ GPVPI 436_ IVSRH 441_ PDPQV 446_ SEQQL 451_ KEAVA 456_ QAVEN 461_ TKFGK 466_ ERHQW 471_ SLEGV 476_ KRLES 481_ SWHGR 486_ PTLEK 491_ EREKN 496_ SAPPH 501_ RRAQK 506_ VMIRS 511_ SSDSS 516_ YMSGS 521_ PGGSP 526_ GSGSA 531_ EKPSS 536_ DVDIS 541_ THSPS 546_ LPLAR 551_ EPVVL 556_ SIASS 561_ RLPQE 566_ SPPLP 571_ ESRDS 576_ HPPLR 581_ LKKSF 586_ EILVR 591_ KPMSS 596_ KPKPP 601_ PRKYF 606_ KSDSD 611_ PQKSL 616_ EEREN 621_ SSCSS 626_ GHTPP 631_ TCGQE 636_ ARELL 641_ PLLLP 646_ QEDTA 651_ GRSPS 656_ ASAGC 661_ PGPGI 666_ GPQTK 671_ SSTEG 676_ EPGWR 681_ RASPV 686_ TQTSP 691_ IKHPL 696_ LKRQA 701_ RMDYS 706_ FDTTA 711_ EDPWV 716_ RISDC 721_ IKNLF 726_ SPIMS 731_ ENHGH 736_ MPLQP 741_ NASLN 746_ EEEGT 751_ QGHPD 756_ GTPPK 761_ LDTAN 766_ GTPKV 771_ YKSAD 776_ SSTVK 781_ KGPPV 786_ APKPA 791_ WFRQS 796_ LKGLR 801_ NRASD 806_ PRGLP 811_ DPALS 816_ TQPAP 821_ ASREH 826_ LGSHI 831_ RASSS 836_ SSSIR 841_ QRISS 846_ FETFG 851_ SSQLP 856_ DKGAQ 861_ RLSLQ 866_ PSSGE 871_ AAKPL 876_ GKHEE 881_ GRFSG 886_ LLGRG 891_ AAPTL 896_ VPQQP 901_ EQVLS 906_ SGSPA 911_ ASEAR 916_ DPGVS 921_ ESPPP 926_ GRQPN 931_ QKTLP 936_ PGPDP 941_ LLRLL 946_ STQAE 951_ ESQGP 956_ VLKMP 961_ SQRAR 966_ SFPLT 971_ RSQSC 976_ ETKLL 981_ DEKTS 986_ KLYSI 991_ SSQVS 996_ SAVMK 1001_ SLLCL 1006_ PSSIS 1011_ CAQTP 1016_ CIPKE 1021_ GASPT 1026_ SSSNE 1031_ DSAAN 1036_ GSAET 1041_ SALDT 1046_ GFSLN 1051_ LSELR 1056_ EYTEG 1061_ LTEAK 1066_ EDDDG 1071_ DHSSL 1076_ QSGQS 1081_ VISLL 1086_ SSEEL 1091_ KKLIE 1096_ EVKVL 1101_ DEATL 1106_ KQLDG 1111_ IHVTI 1116_ LHKEE 1121_ GAGLG 1126_ FSLAG 1131_ GADLE 1136_ NKVIT 1141_ VHRVF 1146_ PNGLA 1151_ SQEGT 1156_ IQKGN 1161_ EVLSI 1166_ NGKSL 1171_ KGTTH 1176_ HDALA 1181_ ILRQA 1186_ REPRQ 1191_ AVIVT 1196_ RKLTP 1201_ EAMPD 1206_ LNSST 1211_ DSAAS 1216_ ASAAS 1221_ DVSVE 1226_ STAEA 1231_ TVCTV 1236_ TLEKM 1241_ SAGLG 1246_ FSLEG 1251_ GKGSL 1256_ HGDKP 1261_ LTINR 1266_ IFKGA 1271_ ASEQS 1276_ ETVQP 1281_ GDEIL 1286_ QLGGT 1291_ AMQGL 1296_ TRFEA 1301_ WNIIK 1306_ ALPDG 1311_ PVTIV 1316_ IRRKS 1321_ LQSKE 1326_TTAAG
1: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4
2: May act as a scaffolding protein that anchors ion channels in the membrane
3: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells