Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)
1_MGDDS 6_ EWLKL 11_ PVDQK 16_ CEHKL 21_ WKARL 26_ SGYEE 31_ ALKIF 36_ QKIKD 41_ EKSPE 46_ WSKFL 51_ GLIKK 56_ FVTDS 61_ NAVVQ 66_ LKGLE 71_ AALVY 76_ VENAH 81_ VAGKT 86_ TGEVV 91_ SGVVS 96_ KVFNQ 101_ PKAKA 106_ KELGI 111_ EICLM 116_ YIEIE 121_ KGEAV 126_ QEELL 131_ KGLDN 136_ KNPKI 141_ IVACI 146_ ETLRK 151_ ALSEF 156_ GSKII 161_ LLKPI 166_ IKVLP 171_ KLFES 176_ REKAV 181_ RDEAK 186_ LIAVE 191_ IYRWI 196_ RDALR 201_ PPLQN 206_ INSVQ 211_ LKELE 216_ EEWVK 221_ LPTSA 226_ PRPTR 231_ FLRSQ 236_ QELEA 241_ KLEQQ 246_ QSAGG 251_ DAEGG 256_ GDDGD 261_ EVPQI 266_ DAYEL 271_ LEAVE 276_ ILSKL 281_ PKDFY 286_ DKIEA 291_ KKWQE 296_ RKEAL 301_ ESVEV 306_ LIKNP 311_ KLEAG 316_ DYADL 321_ VKALK 326_ KVVGK 331_ DTNVM 336_ LVALA 341_ AKCLT 346_ GLAVG 351_ LRKKF 356_ GQYAG 361_ HVVPT 366_ ILEKF 371_ KEKKP 376_ QVVQA 381_ LQEAI 386_ DAIFL 391_ TTTLQ 396_ NISED 401_ VLAVM 406_ DNKNP 411_ TIKQQ 416_ TSLFI 421_ ARSFR 426_ HCTAS 431_ TLPKS 436_ LLKPF 441_ CAALL 446_ KHIND 451_ SAPEV 456_ RDAAF 461_ EALGT 466_ ALKVV 471_ GEKAV 476_ NPFLA 481_ DVDKL 486_ KLDKI 491_ KECSE 496_ KVELI 501_ HGKKA 506_ GLAAD 511_ KKEFK 516_ PLPGR 521_ TAASG 526_ AAGDK 531_ DTKDI 536_ SAPKP 541_ GPLKK 546_ APAAK 551_ AGGPP 556_ KKGKP 561_ AAPGG 566_ AGNTG 571_ TKNKK 576_ GLETK 581_ EIVEP 586_ ELSIE 591_ VCEEK 596_ ASAVL 601_ PPTCI 606_ QLLDS 611_ SNWKE 616_ RLACM 621_ EEFQK 626_ AVELM 631_ DRTEM 636_ PCQAL 641_ VRMLA 646_ KKPGW 651_ KETNF 656_ QVMQM 661_ KLHIV 666_ ALIAQ 671_ KGNFS 676_ KTSAQ 681_ VVLDG 686_ LVDKI 691_ GDVKC 696_ GNNAK 701_ EAMTA 706_ IAEAC 711_ MLPWT 716_ AEQVV 721_ SMAFS 726_ QKNPK 731_ NQSET 736_ LNWLS 741_ NAIKE 746_ FGFSG 751_ LNVKA 756_ FISNV 761_ KTALA 766_ ATNPA 771_ VRTAA 776_ ITLLG 781_ VMYLY 786_ VGPSL 791_ RMFFE 796_ DEKPA 801_ LLSQI 806_ DAEFE 811_ KMQGQ 816_ SPPAP 821_ TRGIS 826_ KHSTS 831_ GTDEG 836_ EDGDE 841_ PDDGS 846_ NDVVD 851_ LLPRT 856_ EISDK 861_ ITSEL 866_ VSKIG 871_ DKNWK 876_ IRKEG 881_ LDEVA 886_ GIIND 891_ AKFIQ 896_ PNIGE 901_ LPTAL 906_ KGRLN 911_ DSNKI 916_ LVQQT 921_ LNILQ 926_ QLAVA 931_ MGPNI 936_ KQHVK 941_ NLGIP 946_ IITVL 951_ GDSKN 956_ NVRAA 961_ ALATV 966_ NAWAE 971_ QTGMK 976_ EWLEG 981_ EDLSE 986_ ELKKE 991_ NPFLR 996_ QELLG 1001_ WLAEK 1006_ LPTLR 1011_ STPTD 1016_ LILCV 1021_ PHLYS 1026_ CLEDR 1031_ NGDVR 1036_ KKAQD 1041_ ALPFF 1046_ MMHLG 1051_ YEKMA 1056_ KATGK 1061_ LKPTS 1066_ KDQVL 1071_ AMLEK 1076_ AKVNM 1081_ PAKPA 1086_ PPTKA 1091_ TSKPM 1096_ GGSAP 1101_ AKFQP 1106_ ASAPA 1111_ EDCIS 1116_ SSTEP 1121_ KPDPK 1126_ KAKAP 1131_ GLSSK 1136_ AKSAQ 1141_ GKKMP 1146_ SKTSL 1151_ KEDED 1156_ KSGPI 1161_ FIVVP 1166_ NGKEQ 1171_ RMKDE 1176_ KGLKV 1181_ LKWNF 1186_ TTPRD 1191_ EYIEQ 1196_ LKTQM 1201_ SSCVA 1206_ KWLQD 1211_ EMFHS 1216_ DFQHH 1221_ NKALA 1226_ VMVDH 1231_ LESEK 1236_ EGVIG 1241_ CLDLI 1246_ LKWLT 1251_ LRFFD 1256_ TNTSV 1261_ LMKAL 1266_ EYLKL 1271_ LFTLL 1276_ SEEEY 1281_ HLTEN 1286_ EASSF 1291_ IPYLV 1296_ VKVGE 1301_ PKDVI 1306_ RKDVR 1311_ AILNR 1316_ MCLVY 1321_ PASKM 1326_ FPFIM 1331_ EGTKS 1336_ KNSKQ 1341_ RAECL 1346_ EELGC 1351_ LVESY 1356_ GMNVC 1361_ QPTPG 1366_ KALKE 1371_ IAVHI 1376_ GDRDN 1381_ AVRNA 1386_ ALNTI 1391_ VTVYN 1396_ VHGDQ 1401_ VFKLI 1406_ GNLSE 1411_ KDMSM 1416_ LEERI 1421_ KRSAK 1426_ RPSAA 1431_ PIKQV 1436_ EEKPQ 1441_ RAQNI 1446_ SSNAN 1451_ MLRKG 1456_ PAEDM 1461_ SSKLN 1466_ QARSM 1471_ SGHPE 1476_ AAQMV 1481_ RREFQ 1486_ LDLDE 1491_ IENDN 1496_ GTVRC 1501_ EMPEL 1506_ VQHKL 1511_ DDIFE 1516_ PVLIP 1521_ EPKIR 1526_ AVSPH 1531_ FDDMH 1536_ SNTAS 1541_ TINFI 1546_ ISQVA 1551_ SGDIN 1556_ TSIQA 1561_ LTQID 1566_ EVLRQ 1571_ EDKAE 1576_ AMSGH 1581_ IDQFL 1586_ IATFM 1591_ QLRLI 1596_ YNTHM 1601_ ADEKL 1606_ EKDEI 1611_ IKLYS 1616_ CIIGN 1621_ MISLF 1626_ QIESL 1631_ AREAS 1636_ TGVLK 1641_ DLMHG 1646_ LITLM 1651_ LDSRI 1656_ EDLEE 1661_ GQQVI 1666_ RSVNL 1671_ LVVKV 1676_ LEKSD 1681_ QTNIL 1686_ SALLV 1691_ LLQDS 1696_ LLATA 1701_ SSPKF 1706_ SELVM 1711_ KCLWR 1716_ MVRLL 1721_ PDTIN 1726_ SINLD 1731_ RILLD 1736_ IHIFM 1741_ KVFPK 1746_ EKLKQ 1751_ CKSEF 1756_ PIRTL 1761_ KTLLH 1766_ TLCKL 1771_ KGPKI 1776_ LDHLT 1781_ MIDNK 1786_ NESEL 1791_ EAHLC 1796_ RMMKH 1801_ SMDQT 1806_ GSKSD 1811_ KETEK 1816_ GASRI 1821_ DEKSS 1826_ KAKVN 1831_ DFLAE 1836_ IFKKI 1841_ GSKEN 1846_ TKEGL 1851_ AELYE 1856_ YKKKY 1861_ SDADI 1866_ EPFLK 1871_ NSSQF 1876_ FQSYV 1881_ ERGLR 1886_ VIEME 1891_ REGKG 1896_ RISTS 1901_ TGISP 1906_ QMEVT 1911_ CVPTP 1916_ TSTVS 1921_ SIGNT 1926_ NGEEV 1931_ GPSVY 1936_ LERLK 1941_ ILRQR 1946_ CGLDN 1951_ TKQDD 1956_ RPPLT 1961_ SLLSK 1966_ PAVPT 1971_ VASST 1976_ DMLHS 1981_ KLSQL 1986_ RESRE 1991_ QHQHS 1996_ DLDSN 2001_ QTHSS 2006_ GTVTS 2011_ SSSTA 2016_ NIDDL 2021_ KKRLE 2026_RIKSS
1: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448)